Combination Assessment of Diffusion-Weighted Imaging and T2-Weighted Imaging Is Acceptable for the Differential Diagnosis of Lung Cancer from Benign Pulmonary Nodules and Masses.
Combination Assessment of Diffusion-Weighted Imaging and T2-Weighted Imaging Is Acceptable for the Differential Diagnosis of Lung Cancer from Benign Pulmonary Nodules and Masses.
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弥散加权成像和t2加权成像联合评估可用于肺癌与良性肺结节和肿块的鉴别诊断。
DOI：
10.3390/cancers13071551
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发表时间：
2021-03-28
期刊：
影响因子：
5.2
通讯作者：
Uramoto H
中科院分区：
文献类型：
--
作者：
Usuda K;Ishikawa M;Iwai S;Iijima Y;Motono N;Matoba M;Doai M;Hirata K;Uramoto H
本研究旨在探讨DWI与T2WI联合评估是否能提高良性肺结节与肿块（BPNMs）鉴别诊断肺癌的能力。使用OCV （1.470 × 10−3 mm2/s）诊断ADC，灵敏度为83.9%(220/262)，特异度为63.4%(33/52)，准确度为80.6%（253/314）。使用OCV（2.45）诊断T2 CR的敏感性为89.7%(235/262)，特异性为61.5%(32/52)，准确率为85.0%（267/314）。经DWI和T2WI诊断为恶性的PNMs 212例中，肺癌203例（95.8%）。经DWI和T2WI诊断为良性的PNMs 33例中，23例（69.7%）为良性PNMs。DWI与T2WI联合检查能更准确地判断PNMs，可用于PNMs的鉴别诊断。本研究旨在探讨DWI与T2WI联合评估是否能提高良性肺结节与肿块（BPNMs）鉴别诊断肺癌的能力。鉴别诊断的最佳截止值（OCV）为表观扩散系数（ADC）为1.470 × 10−3 mm2/s， T2对比度（T2 CR）为2.45。肺癌的ADC（1.24±0.29 × 10−3 mm2/s）明显低于BPNM的ADC（1.69±0.58 × 10−3 mm2/s）。肺癌组T2 CR（2.01±0.52）明显低于BPNM组（2.74±1.02）。使用OCV诊断ADC的敏感性为83.9%(220/262)，特异性为63.4%(33/52)，准确性为80.6%（253/314）。使用OCV诊断T2 CR的敏感性为89.7%(235/262)，特异性为61.5%(32/52)，准确率为85.0%（267/314）。经DWI和T2WI诊断为恶性的PNMs 212例中，肺癌203例（95.8%）。经DWI和T2WI诊断为良性的PNMs 33例中，23例（69.7%）为良性PNMs。DWI与T2WI联合检查能更准确地判断PNMs，可用于PNMs的鉴别诊断。
The purpose of this study is to determine whether the combination assessment of DWI and T2WI improves the diagnostic ability for differential diagnosis of lung cancer from benign pulmonary nodules and masses (BPNMs). As using the OCV (1.470 × 10−3 mm2/s) for ADC, the sensitivity was 83.9% (220/262), the specificity 63.4% (33/52), and the accuracy 80.6% (253/314). As using the OCV (2.45) for T2 CR, the sensitivity was 89.7% (235/262), the specificity 61.5% (32/52), and the accuracy 85.0% (267/314). In 212 PNMs which were judged to be malignant by both DWI and T2WI, 203 PNMs (95.8%) were lung cancers. In 33 PNMs which were judged to be benign by both DWI and T2WI, 23 PNMs (69.7%) were BPNMs. The combined assessment of DWI and T2WI could judge PNMs more precisely and would be acceptable for differential diagnosis of PNMs. The purpose of this study is to determine whether the combination assessment of DWI and T2-weighted imaging (T2WI) improves the diagnostic ability for differential diagnosis of lung cancer from benign pulmonary nodules and masses (BPNMs). The optimal cut-off value (OCV) for differential diagnosis was set at 1.470 × 10−3 mm2/s for apparent diffusion coefficient (ADC), and at 2.45 for T2 contrast ratio (T2 CR). The ADC (1.24 ± 0.29 × 10−3 mm2/s) of lung cancer was significantly lower than that (1.69 ± 0.58 × 10−3 mm2/s) of BPNM. The T2 CR (2.01 ± 0.52) of lung cancer was significantly lower than that (2.74 ± 1.02) of BPNM. As using the OCV for ADC, the sensitivity was 83.9% (220/262), the specificity 63.4% (33/52), and the accuracy 80.6% (253/314). As using the OCV for T2 CR, the sensitivity was 89.7% (235/262), the specificity 61.5% (32/52), and the accuracy 85.0% (267/314). In 212 PNMs which were judged to be malignant by both DWI and T2WI, 203 PNMs (95.8%) were lung cancers. In 33 PNMs which were judged to be benign by both DWI and T2WI, 23 PNMs (69.7%) were BPNMs. The combined assessment of DWI and T2WI could judge PNMs more precisely and would be acceptable for differential diagnosis of PNMs.
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