Measuring the acoustoelectric interaction constant using ultrasound current source density imaging.

Measuring the acoustoelectric interaction constant using ultrasound current source density imaging.
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DOI:
10.1088/0031-9155/57/19/5929
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发表时间:
2012-10-07
影响因子:
3.5
通讯作者:
Witte R
Witte R
中科院分区:
工程技术2区
文献类型:
--
作者:
Li Q;Olafsson R;Ingram P;Wang Z;Witte R

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Ultrasound Current Source Density Imaging (UCSDI) exploits the acoustoelectric (AE) effect, an interaction between ultrasound pressure and electrical resistivity, to map electrical conduction in the heart. The conversion efficiency for UCSDI is determined by the AE interaction constant K, a fundamental property of all materials; K directly affects the magnitude of the detected voltage signal in UCSDI. This paper describes a technique for measuring K in biological tissue, and reports its value for the first time in cadaver hearts. A custom chamber was designed and fabricated to control the geometry for estimating K, which was measured in different ionic salt solutions and 7 cadaver rabbit hearts. We found K to be strongly dependent on concentration for the divalent salt CuSO4, but not for the monovalent salt NaCl, consistent with their different chemical properties. In the rabbit heart, K was determined to be 0.041±0.012 %/MPa, similar to the measurement of K in physiologic saline (0.034±0.003 %/MPa). This study provides a baseline estimate of K for modeling and experimental studies that involve UCSDI to map cardiac conduction and reentry currents associated with arrhythmias.
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期刊: PHYSICAL REVIEW
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