Risk factors for fracture in middle-age and older-age men of African descent.
Risk factors for fracture in middle-age and older-age men of African descent.
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DOI：
10.1002/jbmr.2016
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发表时间：
2014-01
影响因子：
6.2
通讯作者：
Zmuda, Joseph M.
中科院分区：
文献类型：
--
作者：
Sheu, Yahtyng;Cauley, Jane A.;Patrick, Alan L.;Wheeler, Victor W.;Bunker, Clareann H.;Zmuda, Joseph M.
尽管与欧洲人相比，非洲人后裔的骨折发生率较低，但非洲人后裔骨折后的发病率和死亡率可能更高。然而，骨折风险和相关的临床风险因素在非洲裔人群中尚未明确界定，特别是在非洲裔男性中。我们使用从多巴哥骨健康研究收集的数据来检查偶发性骨折的潜在临床危险因素，包括人口统计信息、人体测量、病史、生活方式因素、骨矿物质密度（BMD）和髋部结构几何。在1933名研究入组时年龄≥40岁的非裔加勒比男性中（平均年龄：57.2±11.0岁），65名在随后的10年随访中报告了至少一次新的骨折。年龄较小、非洲-加勒比混血、既往骨折史、骨密度和髋部结构几何是发生偶发性骨折的显著危险因素。在调整年龄后，几个骨骼参数（髋关节骨密度、横截面积、外径、皮质厚度和屈曲比）的一个标准差变化分别与35%至56%的意外骨折风险增加相关。在随访期间，有骨折史的男性发生新骨折的可能性高出3倍，在调整了年龄、非洲-加勒比混血血统和骨骼参数后，这种关联仍然很强（风险比范围为2.72-2.82）。我们的研究结果表明，除年龄外，非洲裔男性骨折的危险因素与高加索人群中已确定的危险因素相似。既往骨折史是非洲裔男性偶发性骨折的一个强大而独立的危险因素，可以很容易地纳入临床风险评估。
Although fracture rates are lower in individuals of African descent compared to individuals of European ancestry, morbidity and mortality following a fracture may be greater in African ancestry individuals. However, fracture risk and associated clinical risk factors have not been well-defined among African ancestry populations, especially among African ancestry men. We used data collected from the Tobago Bone Health Study to examine potential clinical risk factors for incident fractures including demographic information, anthropometric measurements, medical history, lifestyle factors, bone mineral density (BMD) and hip structural geometry. Among 1,933 Afro-Caribbean men aged ≥40 years at study entry (mean age: 57.2 ± 11.0 years), 65 reported at least one new fracture during 10 years of subsequent follow-up. Younger age, mixed Afro-Caribbean ancestry, prior fracture history, BMD and hip structural geometry were statistically significant risk factors for incident fractures. One Standard deviation change in several skeletal parameters (hip BMD, cross-sectional area, outer diameter, cortical thickness and buckling ratio) were each associated with a 35% to 56% increase in incident fracture risk after adjusting for age. Men with a prior fracture history were 3 times more likely to experience a new fracture during follow-up, and the association remained strong after adjusting for age, mixed Afro-Caribbean ancestry and skeletal parameters (hazard ratios ranged 2.72–2.82). Our findings suggest that except for age, risk factors for fracture in men of African ancestry are similar to established risk factors in Caucasian populations. Prior fracture history is a powerful and independent risk factor for incident fractures among African ancestry men and could easily be incorporated into clinical risk evaluation.
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影响因子：
6.2
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Danielson, Michelle E;Beck, Thomas J;Lian, Yinjuan;Karlamangla, Arun S;Greendale, Gail A;Ruppert, Kristine;Lo, Joan;Greenspan, Susan;Vuga, Marike;Cauley, Jane A
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通讯作者：
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