Sudden infant death syndrome and Ljungan virus
Sudden infant death syndrome and Ljungan virus
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婴儿猝死综合症和永安病毒
DOI：
10.1007/s12024-009-9086-8
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
W. Klitz
中科院分区：
文献类型：
--
作者：
B. Niklasson;P. Almqvist;B. Hörnfeldt;W. Klitz
最近研究表明，永干病毒（LV）与其自然啮齿动物宿主的围产期死亡以及实验室小鼠的生殖发育障碍有关。瑞典小型啮齿类动物丰度与人类宫内胎儿死亡（IUFD）发生率之间存在很强的流行病学关联。在所检测的IUFD病例中有一半检出LV抗原。因此，提出了婴儿猝死综合症（SIDS）是否可能与啮齿类动物的丰富有关以及SIDS病例中是否存在病毒的问题。使用瑞典死因数据库的小岛屿发展中国家的发病率的变化跟踪本地啮齿动物的人口波动的变化。使用LV特异性免疫组织化学（IHC）对SIDS、SIDS伴心肌淋巴细胞浸润（心肌炎）和心肌炎病例的脑、心脏和肺福尔马林固定组织进行了研究。在使用IHC研究的所有三种患者类别的脑、心脏和肺组织中均检测到Ljungan病毒。这些研究表明，LV可能在婴儿死亡中起重要作用，IUFD和SIDS可能具有共同的病因学基础。
Ljungan virus (LV) has recently been associated with perinatal death in its natural rodent reservoir and also with developmental disorders of reproduction in laboratory mice. A strong epidemiological association has been found between small rodent abundance in Sweden and the incidence of intrauterine fetal death (IUFD) in humans. LV antigen has been detected in half of the IUFD cases tested. The question was therefore raised whether sudden infant death syndrome (SIDS) might be associated with rodent abundance, and whether the virus is present in cases of SIDS. Variation in the incidence of SIDS using the Swedish cause-of-death database tracked the changes in the population fluctuations of native rodents. Formalin-fixed tissues from the brain, heart, and lung were investigated from cases of SIDS, SIDS with lymphocytic infiltration of the myocardium (myocarditis) and myocarditis cases using LV specific immunohistochemistry (IHC). Ljungan virus was detected in the brain, heart, and lung tissue from all three of the patient categories investigated using IHC. These studies suggest that LV may play a prominent role in infant death, and that IUFD and SIDS may have common etiological underpinnings.
Ljungan 病毒感染小鼠的宫内死亡、胎儿畸形和延迟妊娠。
DOI：
10.1002/bdrb.20083
发表时间：
2006
期刊：
Birth defects research. Part B, Developmental and reproductive toxicology.
影响因子：
--
作者：
Samsioe,Annika;Feinstein,Ricardo;Saade,George;Sjoholm,Ake;Hornfeldt,Birger;Fundele,Reinald;Klitz,William;Niklasson,Bo
通讯作者：
Niklasson,Bo
影响因子：
5
作者：
Rhodes, Troy E.;Abraham, Robert L.;George, Alfred L., Jr.
通讯作者：
George, Alfred L., Jr.
影响因子：
120.7
作者：
Paterson, David S.;Trachtenberg, Felicia L.;Kinney, Hannah C.
通讯作者：
Kinney, Hannah C.