Elevated arteriolar cerebral blood volume in prodromal Huntington's disease.
Elevated arteriolar cerebral blood volume in prodromal Huntington's disease.
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DOI：
10.1002/mds.25591
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发表时间：
2014-03
影响因子：
8.6
通讯作者：
Ross, Christopher A.
中科院分区：
文献类型：
--
作者：
Hua, Jun;Unschuld, Paul G.;Margolis, Russell L.;van Zijl, Peter C. M.;Ross, Christopher A.
神经血管改变与亨廷顿病（HD）的病理生理学有关。由于小动脉对代谢变化最敏感，因此小动脉脑血容量（CBVa）是脑血管调节的重要指标。这项初步研究旨在研究前驱HD中潜在的神经血管（CBVa）异常，并将其与广泛使用的成像标志物脑萎缩进行比较。在7名前驱HD患者和9名年龄匹配的对照组中，采用超高场（7T）磁共振成像测量CBVa和脑体积。前驱HD患者的皮质CBVa显著升高（相对差异= 38.5%，效应量=1.48）。额叶皮层CBVa与遗传指标之间存在显著相关性。相比之下，在这些前驱HD患者中未检测到显著的脑萎缩。CBVa在前驱HD中可能是异常的，甚至在实质性脑萎缩发生之前。进一步的研究，更大的队列和纵向随访是值得的，以确定它是否可以作为一个潜在的生物标志物的临床试验。
Neurovascular alterations have been implicated in the pathophysiology of Huntington’s Disease (HD). As arterioles are most responsive to metabolic alterations, arteriolar-cerebral-blood-volume (CBVa) is an important indicator of cerebrovascular regulation. This pilot study is intended to investigate potential neurovascular (CBVa) abnormality in prodromal-HD, and compare it with the widely used imaging marker brain atrophy. CBVa and brain volumes were measured with ultra-high field (7T) magnetic-resonance-imaging in seven prodromal-HD patients and nine age-matched controls. Cortical CBVa was significantly elevated in prodromal-HD patients (relative difference=38.5%, effect size=1.48). Significant correlations were found between CBVa in frontal cortex and genetic measures. By contrast, no significant brain atrophy was detected in these prodromal-HD patients. CBVa may be abnormal in prodromal-HD, even before substantial brain atrophy occurs. Further investigation with a larger cohort and longitudinal follow-up is merited to determine whether it could be used as a potential biomarker for clinical trials.
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影响因子：
6.3
作者：
Donahue, Manus J.;Sideso, Ediri;Jezzard, Peter
通讯作者：
Jezzard, Peter
DOI：
10.1523/jneurosci.0388-12.2012
发表时间：
2012-05-09
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Cepeda-Prado E;Popp S;Khan U;Stefanov D;Rodríguez J;Menalled LB;Dow-Edwards D;Small SA;Moreno H
通讯作者：
Moreno H
影响因子：
6.6
作者：
Niatsetskaya, Zoya;Basso, Manuela;Ratan, Rajiv R.
通讯作者：
Ratan, Rajiv R.
影响因子：
3.5
作者：
Langbehn, DR;Brinkman, RR;Hayden, MR
通讯作者：
Hayden, MR
影响因子：
2.9
作者：
Hua, Jun;Qin, Qin;van Zijl, Peter C. M.
通讯作者：
van Zijl, Peter C. M.