CREM Is Correlated With Immune-Suppressive Microenvironment and Predicts Poor Prognosis in Gastric Adenocarcinoma.
CREM Is Correlated With Immune-Suppressive Microenvironment and Predicts Poor Prognosis in Gastric Adenocarcinoma.
复制标题
CREM 与免疫抑制微环境相关，可预测胃腺癌的不良预后。
DOI：
10.3389/fcell.2021.697748
复制
发表时间：
2021
影响因子：
5.5
通讯作者：
Le A
中科院分区：
文献类型：
--
作者：
Yu K;Kuang L;Fu T;Zhang C;Zhou Y;Zhu C;Zhang Q;Zhang Z;Le A
转录抑制因子cAMP反应元件调节剂(CREM)在T细胞发育中起重要作用。在本研究中，我们利用整合的生物信息学方法来探讨CREM在胃腺癌中的作用。我们的结果表明，CREM的高表达与GAC的总体生存状况密切相关。通过GSEA聚类分析，我们发现CREM的高表达与GAC的致癌途径有关。单细胞测序数据表明，CREM主要定位于耗竭的CD8+T细胞。其预后价值和潜在功能导致肿瘤微环境(TME)中T细胞耗竭。在胶质瘤和肺癌中也得到了类似的结果。CREM的高表达与GAC的临床相关性，与GAC的T细胞耗竭和M2极化有关。提示CREM可作为判断GAC预后的生物标志物，为探讨GAC的发病机制提供了新的方向。
The transcriptional repressor cAMP response element modulator (CREM) has an important role in T-cell development. In this study, we used the integrated Bioinformatics Methods to explore the role of CREM in gastric adenocarcinoma (GAC). Our results showed that high CREM expression was closely related with poorer overall survival in GAC. By GSEA cluster analysis, we found that the high expression of CREM was associated with the cancer-associated pathway in GAC. Moreover, single-cell sequencing data showed that CREM is mainly localized in exhausted CD8+ T cells. Its prognostic value and the potential function lead to T-cell exhaustion in the tumor microenvironment (TME). Similar results were also obtained in glioma and lung cancer. High expression of CREM, correlated with clinical relevance of GAC, was associated with T-cell exhaustion and M2 polarization in GAC. These findings suggest that CREM can be used as a prognostic biomarker in GAC, which might provide a novel direction to explore the pathogenesis of GAC.
登录
查看更多内容
TISCH：一个全面的网络资源，可实现肿瘤微环境的交互式单细胞转录组可视化
影响因子：
14.9
作者：
Sun D;Wang J;Han Y;Dong X;Ge J;Zheng R;Shi X;Wang B;Li Z;Ren P;Sun L;Yan Y;Zhang P;Zhang F;Li T;Wang C
通讯作者：
Wang C
影响因子：
4.8
作者：
Rauen, Thomas;Benedyk, Konrad;Tenbrock, Klaus
通讯作者：
Tenbrock, Klaus
影响因子：
5.4
作者：
Bodor, Josef;Fehervari, Zoltan;Sakaguchi, Shimon
通讯作者：
Sakaguchi, Shimon
影响因子：
4.3
作者：
Yazici, Ozan;Sendur, M. Ali Nahit;Aksoy, Sercan
通讯作者：
Aksoy, Sercan
影响因子：
14.9
作者：
Xie C;Mao X;Huang J;Ding Y;Wu J;Dong S;Kong L;Gao G;Li CY;Wei L
通讯作者：
Wei L