Activation of immune responses to brain antigens after stroke.
Activation of immune responses to brain antigens after stroke.
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DOI：
10.1111/j.1471-4159.2012.07953.x
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发表时间：
2012-11
影响因子：
4.7
通讯作者：
Becker KJ
中科院分区：
文献类型：
--
作者：
Becker KJ
Infection is common after stroke and is independently associated with a worse outcome. The predisposition to infection following stroke is in part related to a sympathetically mediated suppression of the peripheral immune response. The teleological explanation for this immune dysfunction is that it serves to prevent autoimmune responses to brain antigens. We believe that the systemic immune response in patients who develop infection, however, thwarts this seemingly protective response and predisposes to central nervous system autoimmunity. These autoimmune responses may mediate, at least in part, the worse outcome associated with post-stroke infection.
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