Medial Temporal Lobe Epilepsy
Medial Temporal Lobe Epilepsy
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内侧颞叶癫痫
DOI：
10.1002/9780470975039.ch14
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
W. Tatum
中科院分区：
文献类型：
--
作者：
W. Tatum
颞叶癫痫（TLE）是成人定位相关癫痫的最常见形式。海马发作占所有颞叶癫痫发作的至少 80%。内侧 TLE 的脑电图 (EEG) 包含发作间期特征，通常与基底颞电极上具有最大电压的前颞癫痫样放电相关。头皮脑电图上的局部发作模式特征性地显示单侧 5 至 9 Hz 节律性发作 θ 或 α 癫痫样活动在前颞头皮电极中最大。侵入性头皮脑电图比较产生了有关内侧时间源及其相应电场的直接信息。宏观空间和时间分辨率的细化表明，在常规头皮记录中观察到的 1 至 35 Hz 频率之外可能存在更精确的癫痫定位。定义内侧颞叶内的突发发生的焦点区域表明了与超越内侧结构甚至颞叶本身的广泛网络的丰富联系。先进的电生理学在 TLE 中的应用可能会进一步加深我们对癫痫发生的理解，以完善手术治疗并阐明癫痫发生本身的神经生理学推论。
Temporal lobe epilepsy (TLE) is the most common form of adult localization-related epilepsy. Hippocampal onset accounts for at least 80% of all temporal lobe seizures. The electroencephalogram (EEG) of mesial TLE contains interictal features often associated with anterior temporal epileptiform discharges with a maximal voltage over the basal temporal electrodes. Localized ictal patterns on scalp EEGs characteristically reveal unilateral 5-to 9-Hz rhythmic ictal theta or alpha epileptiform activity maximal in the anterior temporal scalp electrodes. Invasive-scalp EEG comparisons have yielded direct information about mesial temporal sources and their corresponding electrical fields. Refinement of macroscopic spatial and the temporal resolution suggest that a more precise seizure localization may exist beyond 1-to 35-Hz frequencies observed in routine scalp recording. Defining the focal areas of ictogenesis within the medial temporal lobe demonstrates a rich connection to a broad network that goes beyond the medial structures and even the temporal lobe itself. Advanced electrophysiologic application in TLE may further our understanding of ictogenesis to perfect surgical treatment and to elucidate the neurophysiologic corollaries of epileptogensis itself.
影响因子：
5.6
作者：
Berg, Anne T.;Berkovic, Samuel F.;Scheffer, Ingrid E.
通讯作者：
Scheffer, Ingrid E.
影响因子：
158.5
作者：
Wiebe, S;Blume, WT;Eliasziw, M
通讯作者：
Eliasziw, M