Diabetic Cardiomyopathy: Does the Type of Diabetes Matter?
Diabetic Cardiomyopathy: Does the Type of Diabetes Matter?
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DOI：
10.3390/ijms17122136
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发表时间：
2016-12-18
影响因子：
5.6
通讯作者：
Bugger H
中科院分区：
文献类型：
--
作者：
Hölscher ME;Bode C;Bugger H
近年来，2型糖尿病已发展为一种快速增长的流行病，其与肥胖症的患病率增加并行，并且显著增加了地球仪上心血管疾病的风险。虽然缺血性心脏病是糖尿病受试者死亡的主要原因，但糖尿病心肌病（DC）总结了糖尿病对心脏的不良影响，这些不良影响与冠状动脉疾病（CAD）和高血压无关。DC增加了心力衰竭（HF）的风险，并可能导致射血分数保留型心力衰竭（HFpEF）和射血分数降低型心力衰竭（HFrEF）。已经提出了许多分子机制来支持DC，这些机制与被认为有助于心力衰竭的机制部分重叠。尽管如此，DC的存在仍然是一个有争议的话题，尽管DC的临床相关性越来越多地被科学家和临床医生所认识。此外，相对较少的关注已归因于这样的事实，即DC的潜在机制和临床特征可能在1型糖尿病与2型糖尿病中部分不同。在下面的综述中，我们将讨论两种不同类型的糖尿病背景下人类DC存在的临床和临床前文献。
In recent years, type 2 diabetes mellitus has evolved as a rapidly increasing epidemic that parallels the increased prevalence of obesity and which markedly increases the risk of cardiovascular disease across the globe. While ischemic heart disease represents the major cause of death in diabetic subjects, diabetic cardiomyopathy (DC) summarizes adverse effects of diabetes mellitus on the heart that are independent of coronary artery disease (CAD) and hypertension. DC increases the risk of heart failure (HF) and may lead to both heart failure with preserved ejection fraction (HFpEF) and reduced ejection fraction (HFrEF). Numerous molecular mechanisms have been proposed to underlie DC that partially overlap with mechanisms believed to contribute to heart failure. Nevertheless, the existence of DC remains a topic of controversy, although the clinical relevance of DC is increasingly recognized by scientists and clinicians. In addition, relatively little attention has been attributed to the fact that both underlying mechanisms and clinical features of DC may be partially distinct in type 1 versus type 2 diabetes. In the following review, we will discuss clinical and preclinical literature on the existence of human DC in the context of the two different types of diabetes mellitus.
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影响因子：
5
作者：
Bugger H;Riehle C;Jaishy B;Wende AR;Tuinei J;Chen D;Soto J;Pires KM;Boudina S;Theobald HA;Luptak I;Wayment B;Wang X;Litwin SE;Weimer BC;Abel ED
通讯作者：
Abel ED
影响因子：
7.7
作者：
Bugger H;Boudina S;Hu XX;Tuinei J;Zaha VG;Theobald HA;Yun UJ;McQueen AP;Wayment B;Litwin SE;Abel ED
通讯作者：
Abel ED
影响因子：
8.2
作者：
Bugger, Heiko;Abel, E. Dale
通讯作者：
Abel, E. Dale
影响因子：
2.1
作者：
Brunvand L;Fugelseth D;Stensaeth KH;Dahl-Jørgensen K;Margeirsdottir HD
通讯作者：
Margeirsdottir HD
DOI：
10.5507/bp.2003.008
发表时间：
2003-10-01
期刊：
Biomedical Papers (Olomouc)
影响因子：
--
作者：
Berkova, Marie;Opavsky, Jaroslav;Salinger, Jiri
通讯作者：
Salinger, Jiri