Transcriptional Factors Mediating Retinoic Acid Signals in the Control of Energy Metabolism.
Transcriptional Factors Mediating Retinoic Acid Signals in the Control of Energy Metabolism.
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介导视黄酸信号控制能量代谢的转录因子
DOI：
10.3390/ijms160614210
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发表时间：
2015-06-23
影响因子：
5.6
通讯作者：
Chen G
中科院分区：
文献类型：
--
作者：
Zhang R;Wang Y;Li R;Chen G
视黄酸（Retinoic acid， RA）是维生素A （VA）的活性代谢物，在包括能量代谢在内的许多生理过程中起着重要作用。这主要是通过代谢活跃细胞中ra调控的基因表达来实现的。RA主要通过激活核受体超家族中的两个亚家族，即视黄酸受体（RARs）和类视黄X受体（RXRs）来调控基因表达。RAR/RXR异源二聚体或RXR/RXR同源二聚体与RA靶基因启动子中的RA应答元件结合，通过配体结合调节RA应答元件的表达。代谢性疾病如肥胖和2型糖尿病的发展通常与代谢活跃细胞中参与糖脂代谢的基因表达的深刻变化有关。RA调节其中一些基因的表达。近年来，体内和体外研究表明，VA的状态和代谢调节着宏量营养素的代谢。一些研究表明，除了RARs和RXRs外，肝细胞核因子4α、鸡卵白蛋白上游启动子转录因子II和过氧化物酶体增殖物激活受体β/δ可能是介导RA反应的转录因子。在此，我们总结了VA代谢和核受体在RA信号介导中的作用的最新进展，重点介绍了它们在能量代谢中的意义。
Retinoic acid (RA), an active metabolite of vitamin A (VA), is important for many physiological processes including energy metabolism. This is mainly achieved through RA-regulated gene expression in metabolically active cells. RA regulates gene expression mainly through the activation of two subfamilies in the nuclear receptor superfamily, retinoic acid receptors (RARs) and retinoid X receptors (RXRs). RAR/RXR heterodimers or RXR/RXR homodimers bind to RA response element in the promoters of RA target genes and regulate their expressions upon ligand binding. The development of metabolic diseases such as obesity and type 2 diabetes is often associated with profound changes in the expressions of genes involved in glucose and lipid metabolism in metabolically active cells. RA regulates some of these gene expressions. Recently, in vivo and in vitro studies have demonstrated that status and metabolism of VA regulate macronutrient metabolism. Some studies have shown that, in addition to RARs and RXRs, hepatocyte nuclear factor 4α, chicken ovalbumin upstream promoter-transcription factor II, and peroxisome proliferator activated receptor β/δ may function as transcriptional factors mediating RA response. Herein, we summarize current progresses regarding the VA metabolism and the role of nuclear receptors in mediating RA signals, with an emphasis on their implication in energy metabolism.
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影响因子：
3.6
作者：
Ahuja, HS;Liu, S;Davies, PJA
通讯作者：
Davies, PJA
DOI：
10.1016/j.jsbmb.2005.05.005
发表时间：
2005-09-01
影响因子：
4.1
作者：
Balmer, JE;Blomhoff, R
通讯作者：
Blomhoff, R
影响因子：
4.6
作者：
Brade, Thomas;Kumar, Sandeep;Duester, Gregg
通讯作者：
Duester, Gregg
影响因子：
2.9
作者：
Berry DC;Noy N
通讯作者：
Noy N
影响因子：
64.5
作者：
Bookout, Angie L.;Jeong, Yangsik;Mangelsdorf, David J.
通讯作者：
Mangelsdorf, David J.