Interferon Tau Affects Mouse Intestinal Microbiota and Expression of IL-17.
Interferon Tau Affects Mouse Intestinal Microbiota and Expression of IL-17.
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干扰素 Tau 影响小鼠肠道微生物群和 IL-17 的表达
DOI：
10.1155/2016/2839232
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发表时间：
2016
影响因子：
4.6
通讯作者：
Yin Y
中科院分区：
文献类型：
--
作者：
Ren W;Chen S;Zhang L;Liu G;Hussain T;Hao X;Yin J;Duan J;Tan B;Wu G;Bazer FW;Yin Y
本研究旨在探讨干扰素tau（IFN-tau）对小鼠肠道菌群及白细胞介素17（IL-17）表达的影响。IFNT补充增加了空肠和回肠中的微生物多样性，但降低了粪便中的微生物多样性。IFN-γ对肠道菌群的影响表现在：（1）空肠和回肠中厚壁菌门的比例降低，拟杆菌门的比例增加;（2）结肠和粪便中厚壁菌门的比例增加，拟杆菌门的比例降低;（3）空肠和回肠中乳酸菌的比例降低;（4）增加结肠中布劳特氏菌属、拟杆菌属、Alloprevotella和乳杆菌属的百分比;和（5）增加粪便中乳杆菌属、拟杆菌属和Allobaculum的百分比，同时减少布劳特氏菌属。此外，IFNT补充降低了正常小鼠和肠道病原体感染小鼠肠道中IL-17的表达。总之，IFNT补充调节肠道菌群和肠道IL-17表达，表明IFNT治疗涉及IL-17表达和菌群的肠道疾病的适用性。
This study was conducted to explore the effects of interferon tau (IFNT) on the intestinal microbiota and expression of interleukin 17 (IL-17) in the intestine of mice. IFNT supplementation increased microbial diversity in the jejunum and ileum but decreased microbial diversity in the feces. IFNT supplementation influenced the composition of the intestinal microbiota as follows: (1) decreasing the percentage of Firmicutes and increasing Bacteroidetes in the jejunum and ileum; (2) enhancing the percentage of Firmicutes but decreasing Bacteroidetes in the colon and feces; (3) decreasing Lactobacillus in the jejunum and ileum; (4) increasing the percentage of Blautia, Bacteroides, Alloprevotella, and Lactobacillus in the colon; and (5) increasing the percentage of Lactobacillus, Bacteroides, and Allobaculum, while decreasing Blautia in the feces. Also, IFNT supplementation decreased the expression of IL-17 in the intestines of normal mice and of an intestinal pathogen infected mice. In conclusion, IFNT supplementation modulates the intestinal microbiota and intestinal IL-17 expression, indicating the applicability of IFNT to treat the intestinal diseases involving IL-17 expression and microbiota.
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影响因子：
4.8
作者：
Chang SH;Dong C
通讯作者：
Dong C
影响因子：
3.7
作者：
Hara K;Shirasuna K;Usui F;Karasawa T;Mizushina Y;Kimura H;Kawashima A;Ohkuchi A;Matsuyama S;Kimura K;Takahashi M
通讯作者：
Takahashi M
影响因子：
64.8
作者：
Chassaing B;Koren O;Goodrich JK;Poole AC;Srinivasan S;Ley RE;Gewirtz AT
通讯作者：
Gewirtz AT
膳食 L-谷氨酰胺补充剂可调节微生物群落并激活小鼠肠道的先天免疫
影响因子：
3.5
作者：
Ren, Wenkai;Duan, Jielin;Wu, Guoyao
通讯作者：
Wu, Guoyao
影响因子：
64.5
作者：
Dang EV;Barbi J;Yang HY;Jinasena D;Yu H;Zheng Y;Bordman Z;Fu J;Kim Y;Yen HR;Luo W;Zeller K;Shimoda L;Topalian SL;Semenza GL;Dang CV;Pardoll DM;Pan F
通讯作者：
Pan F