Scalable imprinting of shape-specific polymeric nanocarriers using a release layer of switchable water solubility.
Scalable imprinting of shape-specific polymeric nanocarriers using a release layer of switchable water solubility.
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DOI：
10.1021/nn2049152
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发表时间：
2012-03-27
期刊：
影响因子：
17.1
通讯作者：
Roy K
中科院分区：
文献类型：
--
作者：
Agarwal R;Singh V;Jurney P;Shi L;Sreenivasan SV;Roy K
制备形状特异性的聚合物纳米和微粒以有效地递送药物和成像剂的兴趣越来越大。这些颗粒的大小和形状可以显着影响其运输特性，并在体内生物分布，靶向和细胞摄取中发挥重要作用。纳米压印光刻方法，如喷射和闪光压印光刻（J-FIL），提供了通用的自上而下的工艺来制造形状特异性的、生物相容性的纳米级水凝胶，其可以响应于疾病特异性线索递送治疗和诊断分子。然而，这种纳米载体的自上而下制造的关键挑战是生物和生物相容性材料的可扩展压印，使用水性和有机化学的颗粒表面改性的容易性以及简单但生物相容性的收获。在这里，我们报告说，生物聚合物为基础的牺牲释放层结合改进的纳米载体材料配方可以解决这些挑战。牺牲层由于其通过一价和二价阳离子之间的简单离子交换的可切换溶解度而改善了可扩展性和压印表面改性的容易性。这个过程使得大规模的生物纳米压印和水凝胶纳米颗粒的高效，一步收获水和有机基压印解决方案。
There is increasing interest in fabricating shape-specific polymeric nano and microparticles for efficient delivery of drugs and imaging agents. The size and shape of these particles could significantly influence their transport properties and play an important role in in vivo biodistribution, targeting and cellular uptake. Nanoimprint lithography methods, such as Jet-and-flash imprint lithography (J-FIL), provide versatile top-down processes to fabricate shape-specific, biocompatible nanoscale hydrogels that can deliver therapeutic and diagnostic molecules in response to disease-specific cues. However, the key challenges in top-down fabrication of such nanocarriers are scalable imprinting with biological and biocompatible materials, ease of particle-surface modification using both aqueous and organic chemistry as well as simple yet biocompatible harvesting. Here we report that a biopolymer-based sacrificial release layer in combination with improved nanocarrier-material formulation can address these challenges. The sacrificial layer improves scalability and ease of imprint-surface modification due to its switchable solubility through simple ion exchange between monovalent and divalent cations. This process enables large-scale bio-nanoimprinting and efficient, one-step harvesting of hydrogel nanoparticles in both water- and organic-based imprint solutions.
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由于异常高的化学治疗载荷，有效的工程PLGA纳米颗粒。
影响因子：
10.8
作者：
Enlow EM;Luft JC;Napier ME;DeSimone JM
通讯作者：
DeSimone JM
DOI：
10.1002/wnan.40
发表时间：
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影响因子：
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作者：
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影响因子：
3.4
作者：
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