Clinicopathological characteristics and outcomes of Chinese patients with scanty immune deposits lupus nephritis: a large cohort study from a single center.
Clinicopathological characteristics and outcomes of Chinese patients with scanty immune deposits lupus nephritis: a large cohort study from a single center.
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中国免疫沉积不足狼疮性肾炎患者的临床病理特征和结果：单中心大型队列研究
DOI：
10.1155/2014/212597
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发表时间：
2014
影响因子：
--
通讯作者：
Zhao M
中科院分区：
文献类型：
--
作者：
Li Q;Song D;Wang F;Tan Y;Yu F;Zhao M
目标。目的：探讨免疫沉积稀少的狼疮性肾炎患者的临床病理特征。方法。回顾性分析免疫沉积稀少的狼疮性肾炎患者的资料。检测血浆ANCA和补体成分。结果。在316例经肾活检证实的狼疮性肾炎患者中，40例诊断为少量免疫沉积。稀疏免疫沉积组血清肌酐值显著高于复合免疫沉积组（P = 0.002），血红蛋白水平显著低于复合免疫沉积组（P = 0.009），细胞月牙值显著高于复合免疫沉积组（P = 0.015）。单纯性免疫沉积组血浆ANCA阳性检出率显著高于免疫复合沉积组（52.5%比10.1%,P < 0.001）。血浆补体成分比较，免疫沉积不足组C1q （P = 0.005）、Bb （P = 0.02）水平显著升高，H因子（P = 0.003）水平显著降低。免疫沉积物稀少组治疗失败率显著高于免疫沉积物组（42.5%比19.20%,P = 0.001）。两组患者的肾脏预后相似。结论。免疫沉积稀少的狼疮性肾炎患者肾损害更为严重。ANCA和补体替代通路的激活可能参与了该病的发病机制。
Objective. To assess clinicopathological characteristics of lupus nephritis patients with scanty immune deposits. Methods. The data of patients with scanty immune deposits lupus nephritis were retrospectively analyzed. Plasma ANCA and complement components were detected. Results. Among 316 cases with renal biopsy-proven lupus nephritis, 40 cases were diagnosed as scanty immune deposits. There were significantly higher value of serum creatinine (P = 0.002) and lower hemoglobin level (P = 0.009) and higher score of cellular crescents (P = 0.015) in scanty immune deposits group compared with immune complex deposits group. The frequency of positive plasma ANCA was significantly higher in scanty immune deposits group than that in immune complex deposits group (52.5% versus 10.1%, P < 0.001). As for comparisons of plasma complement components, there were significantly higher levels of C1q (P = 0.005) and Bb (P = 0.02) and lower level of factor H (P = 0.003) in scanty immune deposits group. The ratio of treatment failure was significantly higher in scanty immune deposits group than that in immune deposits group (42.5% versus 19.20%, P = 0.001). The renal outcomes were similar between the two groups. Conclusions. Patients with scanty immune deposits lupus nephritis had more severe kidney damage. ANCA and activation of complement alternative pathway might be involved in the pathogenesis of the disease.
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DOI：
10.2215/cjn.00790208
发表时间：
2008-09-01
影响因子：
9.8
作者：
Meehan, Shane M.;Chang, Anthony;Javaid, Basit
通讯作者：
Javaid, Basit
影响因子：
2.6
作者：
Nagy, G;Brózik, M;Gergely, P
通讯作者：
Gergely, P
影响因子：
13.2
作者：
Charney, DA;Nassar, G;Nadasdy, T
通讯作者：
Nadasdy, T
影响因子：
3.1
作者：
Ganter, Michael T.;Brohi, Karim;Pittet, Jean-Frangois
通讯作者：
Pittet, Jean-Frangois
影响因子：
--
作者：
BUYON, JP;TAMERIUS, J;ABRAMSON, SB
通讯作者：
ABRAMSON, SB