Association of Atopic Dermatitis and Mental Health Outcomes Across Childhood: A Longitudinal Cohort Study.
Association of Atopic Dermatitis and Mental Health Outcomes Across Childhood: A Longitudinal Cohort Study.
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DOI：
10.1001/jamadermatol.2021.2657
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发表时间：
2021-10-01
期刊：
影响因子：
10.9
通讯作者：
Abuabara K
中科院分区：
文献类型：
--
作者：
Kern C;Wan J;LeWinn KZ;Ramirez FD;Lee Y;McCulloch CE;Langan SM;Abuabara K
研究强调了成人特应性皮炎（AD）与心理健康状况之间的关联。然而，尽管全球儿童特应性皮炎负担沉重，但有关儿童心理健康共病发展的文献有限。
研究儿童期和青春期多个时间点特应性皮炎与内化行为和抑郁症状之间的关系，并探索潜在的中介因素，包括哮喘/鼻炎、睡眠和炎症。
纵向队列研究
英国基于人群的出生队列
来自“雅芳父母与儿童纵向研究”的儿童从出生开始随访，平均持续时间为10.0年（标准差2.9年）
在6个月至18岁之间的11个时间点评估特应性皮炎的年期间患病率和疾病严重程度，通过有关屈侧性皮炎的标准化问题进行测量
抑郁症状通过儿童在10岁至18岁之间的5个时间点对《简短情绪和感受问卷》的自我报告回答进行测量；内化行为通过母亲在4岁至16岁之间的7个时间点对《优势与困难问卷》的情绪症状子分数的报告进行测量。
在11181名儿童中，内化行为和抑郁症状的年期间患病率分别在10.3% - 16.0%和6.0% - 22.1%之间。尽管轻度/中度特应性皮炎与抑郁症状无关，但早在4岁时就与内化行为有关（在调整后的模型中，儿童期的患病几率平均增加29 - 84%）。重度特应性皮炎与抑郁症状（调整优势比2.38，95%置信区间1.21 - 4.72）和内化症状（调整优势比1.90，95%置信区间1.14 - 3.16）有关。睡眠质量介导了部分这种关联，但睡眠时长、哮喘/鼻炎以及炎症标志物（白细胞介素 - 6和C反应蛋白）的差异并不能解释这种关联。
在英国一个基于人群的出生队列中，重度特应性皮炎与整个儿童期和青春期的抑郁症状和内化行为有关。即使是儿童期早期患有轻度特应性皮炎的儿童，内化症状的风险也会增加，这凸显了治疗该人群的医生对行为/心理健康意识的重要性。
Research has highlighted associations between atopic dermatitis (AD) and mental health conditions in adults. However, literature on the development of mental health comorbidities in children is limited despite the large burden of pediatric AD worldwide. To examine the relationship between AD and internalizing behaviors and symptoms of depression at multiple time points across childhood and adolescence, and to explore potential mediating factors including asthma/rhinitis, sleep, and inflammation. Longitudinal cohort study Population-based birth cohort in the United Kingdom Children followed from birth for a mean duration of 10.0 years (SD 2.9 years) from The Avon Longitudinal Study of Parents and Children AD annual period prevalence and disease severity assessed at 11 time points between ages 6 months and 18 years, measured by standardized questions about flexural dermatitis Symptoms of depression, measured using child-reported responses to the Short Moods and Feelings Questionnaire at five time points between ages 10 and 18 years; and Internalizing behaviors, measured by maternal report of the Emotional Symptoms subscore of the Strength and Difficulties Questionnaire collected at seven time points between ages 4 and 16 years. Among 11,181 children, the annual period prevalence of internalizing behaviors and symptoms of depression ranged from 10.3% to 16.0% and 6.0% to 22.1%, respectively. Although mild/moderate AD was not associated with symptoms of depression, it was associated with internalizing behaviors as early as age 4 (average of 29-84% increased odds across childhood in adjusted models). Severe AD was associated with symptoms of depression (aOR 2.38, 95% CI 1.21-4.72) and internalizing symptoms (aOR 1.90, 95% CI 1.14-3.16). Sleep quality mediated some of this association, but it was not explained by differences in sleep duration, asthma/rhinitis, nor inflammatory markers (IL-6 and CRP). Within a population-based birth cohort in the United Kingdom, severe AD was associated with symptoms of depression and internalizing behaviors throughout childhood and adolescence. Risk of internalizing symptoms was increased even for children with mild AD beginning early in childhood, highlighting the importance of behavioral/mental health awareness in providers treating this population.
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影响因子：
7.6
作者：
BARON, RM;KENNY, DA
通讯作者：
KENNY, DA
影响因子：
2.9
作者：
Hammer-Helmich L;Linneberg A;Obel C;Thomsen SF;Tang Møllehave L;Glümer C
通讯作者：
Glümer C
DOI：
10.1016/j.bbi.2017.11.020
发表时间：
2018-03
期刊：
Brain, behavior, and immunity
影响因子：
--
作者：
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通讯作者：
Jones PB
影响因子：
6.6
作者：
McKenzie, Dean P.;Toumbourou, John W.;Patton, George C.
通讯作者：
Patton, George C.
影响因子：
3.2
作者：
Ahn, Hye-Jin;Shin, Min Kyung;Lew, Bark-Lynn
通讯作者：
Lew, Bark-Lynn