Hormonal therapies and osteoporosis.
Hormonal therapies and osteoporosis.
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激素疗法和骨质疏松症。
DOI：
10.1093/ilar.45.2.170
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发表时间：
2004
期刊：
影响因子：
2.5
通讯作者：
C. Jerome
中科院分区：
文献类型：
--
作者：
C. Jerome
骨质疏松症现在被定义为一种以骨量低和骨组织微结构恶化为特征的疾病，导致骨脆性和骨折风险增加，是一个主要的公共卫生问题。由于长期治疗的风险/效益比，用于预防和治疗与更年期相关的骨质疏松症的经典激素疗法最近受到质疑。迫切需要针对这种疾病的安全有效的替代疗法。非人类灵长类动物已被用作评估与雌激素缺乏相关的骨骼变化的模型，因为它们的小梁骨和皮质骨重塑过程、每月月经周期和生殖激素模式与人类相似。切除卵巢的非人灵长类动物已成为研究骨重塑影响的首选模型，特别是在骨量、结构和强度方面，以满足抗骨质疏松药物开发国际指南要求的研究。非人灵长类动物适用于评估骨量和骨质量的多种方法，包括双能 X 射线吸收测定法 (DXA)、定量计算机断层扫描 (QCT)、组织学、静态和动态组织形态测定法、生物力学测试，以及为临床使用而开发的测定法，这些测定法可作为骨代谢过程的生物标志物。使用非人灵长类动物模型评估骨质疏松症治疗，包括激素（性类固醇及其类似物，甲状旁腺激素）和非激素（双磷酸盐）治疗，提供了有关安全性和有效性以及与雌激素缺乏相关的骨质流失机制的宝贵信息，可直接适用于人类情况。
Osteoporosis, now defined as a disease characterized by low bone mass and a microarchitectural deterioration of bone tissue leading to enhanced bone fragility and fracture risk, is a major public health problem. Classic hormonal therapies to prevent and treat osteoporosis associated with menopause have recently been questioned due to the risk/benefit ratio of prolonged treatment. There is a critical need for safe and effective alternative therapeutics for this disease. Nonhuman primates have been used as models to assess bone changes associated with estrogen deficiency because their trabecular and cortical bone remodeling processes, monthly menstrual cycles, and reproductive-hormone patterns are similar to those of humans. The ovariectomized nonhuman primate has become the preferred model in which to study effects on bone remodeling, particularly with regard to bone mass, architecture, and strength, in fulfillment of studies required by international guidelines for the development of antiosteoporotic drugs. The nonhuman primate is amenable to several methodologies that assess bone quantity and quality, including dual energy x-ray absorptiometry (DXA), quantitative computed tomography (QCT), histology, static and dynamic histomorphometry, and biomechanical testing, as well as assays developed for clinical use, which serve as biomarkers of bone metabolic processes. The use of the nonhuman primate model in the assessment of osteoporosis therapeutics, both hormonal (sex steroids and their analogues, parathyroid hormone) and nonhormonal (bisphosphonates), has provided valuable information on the safety and efficacy as well as the mechanisms of bone loss associated with estrogen deficiency that is directly applicable to the human situation.
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人甲状旁腺激素 (1-34) 肽治疗 6 个月对切除卵巢的食蟹猴（食蟹猴）的效果。
影响因子：
4.1
作者：
Jerome,CP;Johnson,CS;Vafai,HT;Kaplan,KC;Bailey,J;Capwell,B;Fraser,F;Hansen,L;Ramsay,H;Shadoan,M;Lees,CJ;Thomsen,JS;Mosekilde,L
通讯作者：
Mosekilde,L
一种潜在的灵长类动物模型，用于治疗因医学卵巢切除术或绝经而导致的骨质流失。
DOI：
10.1210/jcem-71-1-105
发表时间：
1990
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Mann,DR;Gould,KG;Collins,DC
通讯作者：
Collins,DC
影响因子：
4.1
作者：
Gadeleta, SJ;Boskey, AL;Rimnac, CM
通讯作者：
Rimnac, CM
雌性恒河猴衰老和更年期状态对骨骼的影响。
DOI：
10.1210/jcem.84.11.6151
发表时间：
1999
期刊：
The Journal of clinical endocrinology and metabolism.
影响因子：
--
作者：
Colman,RJ;Kemnitz,JW;Lane,MA;Abbott,DH;Binkley,N
通讯作者：
Binkley,N
使用荧光辅助同步加速器红外显微光谱检查骨质疏松症中的骨化学成分。
DOI：
--
发表时间：
2000
期刊：
Cellular and molecular biology (Noisy-le-Grand, France)
影响因子：
--
作者：
Miller,LM;Tibrewala,J;Carlson,CS
通讯作者：
Carlson,CS