Endogenous retroviruses in trophoblast differentiation and placental development.

Endogenous retroviruses in trophoblast differentiation and placental development.
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DOI:
10.1111/j.1600-0897.2010.00860.x
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发表时间:
2010-10
期刊:
American journal of reproductive immunology (New York, N.Y. : 1989)
影响因子:
--
通讯作者:
Spencer TE
Spencer TE
中科院分区:
其他
文献类型:
--
作者:
Black SG;Arnaud F;Palmarini M;Spencer TE

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内源性逆转录病毒(ERV)存在于所有脊椎动物的基因组中,起源于外源性逆转录病毒对宿主生殖系的感染。ERV与其宿主共同进化了数百万年,并被认为有助于基因组可塑性,保护宿主免受相关病原性和外源性逆转录病毒的感染,并在胎盘发育中发挥重要作用。因此,在整个进化过程中,一些ERV被积极选择并保持在宿主基因组中。本综述将重点关注ERVs在哺乳动物胎盘发育中的关键作用,并特别强调绵羊JSRV相关内源性β逆转录病毒在孕体(胚胎和相关胚外膜)发育中的生物学作用。
Endogenous retroviruses (ERVs) are present in the genome of all vertebrates and originated from infections of the germline of the host by exogenous retroviruses. ERVs have coevolved with their hosts for millions of years and are recognized to contribute to genome plasticity, protect the host against infection of related pathogenic and exogenous retroviruses, and play a vital role in development of the placenta. Consequently, some ERVs have been positively selected and maintained in the host genome throughout evolution. This review will focus on the critical role of ERVs in development of the mammalian placenta and specifically highlight the biological role of sheep JSRV-related endogenous betaretroviruses in conceptus (embryo and associated extraembryonic membranes) development.
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