Deletion at an 1q24 locus reveals a critical role of long noncoding RNA DNM3OS in skeletal development.
Deletion at an 1q24 locus reveals a critical role of long noncoding RNA DNM3OS in skeletal development.
复制标题
1q24 位点的缺失揭示了长非编码 RNA DNM3OS 在骨骼发育中的关键作用
DOI：
10.1186/s13578-021-00559-8
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发表时间：
2021-03-02
影响因子：
7.5
通讯作者：
Cheng SY
中科院分区：
文献类型：
--
作者：
Yu TT;Xu QF;Li SY;Huang HJ;Dugan S;Shao L;Roggenbuck JA;Liu XT;Liu HZ;Hirsch BA;Yue S;Liu C;Cheng SY
背景
Background
Skeletal development and maintenance are complex processes known to be coordinated by multiple genetic and epigenetic signaling pathways. However, the role of long non-coding RNAs (lncRNAs), a class of crucial epigenetic regulatory molecules, has been under explored in skeletal biology.
Results
Here we report a young patient with short stature, hypothalamic dysfunction and mild macrocephaly, who carries a maternally inherited 690 kb deletion at Chr.1q24.2 encompassing a noncoding RNA gene, DNM3OS, embedded on the opposite strand in an intron of the DYNAMIN 3 (DNM3) gene. We show that lncRNA DNM3OS sustains the proliferation of chondrocytes independent of two co-cistronic microRNAs miR-199a and miR-214. We further show that nerve growth factor (NGF), a known factor of chondrocyte growth, is a key target of DNM3OS-mediated control of chondrocyte proliferation.
Conclusions
This work demonstrates that DNM3OS is essential for preventing premature differentiation of chondrocytes required for bone growth through endochondral ossification.
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影响因子：
9
作者：
Lu Z;Lei D;Jiang T;Yang L;Zheng L;Zhao J
通讯作者：
Zhao J
影响因子：
7.2
作者：
Long, Fanxin;Ornitz, David M.
通讯作者：
Ornitz, David M.
DOI：
10.1016/j.jpeds.2016.02.068
发表时间：
2016-06
期刊：
The Journal of pediatrics
影响因子：
--
作者：
Jee YH;Baron J
通讯作者：
Baron J
MiR-214 和 N-ras 调节环抑制横纹肌肉瘤细胞生长和异种移植肿瘤发生。
影响因子：
--
作者：
Huang HJ;Liu J;Hua H;Li SE;Zhao J;Yue S;Yu TT;Jin YC;Cheng SY
通讯作者：
Cheng SY
DOI：
10.1038/nrd4140
发表时间：
2013-11
期刊：
Nature reviews. Drug discovery
影响因子：
--
作者：
Ling H;Fabbri M;Calin GA
通讯作者：
Calin GA