Post-stress rumination predicts HPA axis responses to repeated acute stress.
Post-stress rumination predicts HPA axis responses to repeated acute stress.
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DOI：
10.1016/j.psyneuen.2014.07.021
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发表时间：
2014-11
影响因子：
3.7
通讯作者：
Rohleder, Nicolas
中科院分区：
文献类型：
--
作者：
Gianferante, Danielle;Thoma, Myriam V.;Hanlin, Luke;Chen, Xuejie;Breines, Juliana G.;Zoccola, Peggy M.;Rohleder, Nicolas
关键词：
下丘脑-垂体-肾上腺（HPA）轴不能适应反复的压力暴露与不良的健康结果有关，但我们对非习惯性的预测因素的了解是有限的。反刍，被定义为重复和不必要的以过去为中心的消极思维，与夸大的HPA轴压力反应和不良的健康结果有关。本研究的目的是检验应激后反刍是否与皮质醇对重复应激暴露的非习惯化有关。27名参与者（n=13名女性）在连续的下午进行了两次特里尔社会压力测试（TSST）。在第一次TSST后测量应激后反刍，并通过测量两次TSST前1分钟和后1、10、20、60和120分钟的唾液皮质醇来评估HPA轴反应。应激暴露在这两天诱导HPA轴激活，并且该激活显示出对第二TSST的较低反应所指示的习惯化（F= 3.7，p= 0.015）。第一次TSST后的应激后反刍与初始应激试验后更大的皮质醇反应性相关（r = 0.45，p < 0.05），与第二次TSST后皮质醇反应性增加相关（r = 0.51，p < 0.01），表明非习惯性，与年龄、性别、抑郁症状、感知生活压力和特质反刍无关。总之，结果表明，反刍应激后预测HPA轴反应的非习惯化。这一发现暗示反刍作为一种可能的机制介导适应不良的压力反应模式，它也可能提供一个途径，通过反刍可能导致负面的健康结果。
Failure of the hypothalamus-pituitary-adrenal (HPA) axis to habituate to repeated stress exposure is related with adverse health outcomes, but our knowledge of predictors of non-habituation is limited. Rumination, defined as repetitive and unwanted past-centered negative thinking, is related with exaggerated HPA axis stress responses and poor health outcomes. The aim of this study was to test whether post-stress rumination was related with non-habituation of cortisol to repeated stress exposure. Twenty-seven participants (n=13 females) were exposed to the Trier Social Stress Test (TSST) twice on consecutive afternoons. Post-stress rumination was measured after the first TSST, and HPA axis responses were assessed by measuring salivary cortisol 1 minute before, and 1, 10, 20, 60, and 120 minutes after both TSSTs. Stress exposure induced HPA axis activation on both days, and this activation showed habituation indicated by lower responses to the second TSST (F= 3.7, p=.015). Post-stress rumination after the first TSST was associated with greater cortisol reactivity after the initial stress test (r = 0.45, p < 0.05) and with increased cortisol responses to the second TSST (r = 0.51, p < 0.01), indicating non-habituation, independently of age, sex, depressive symptoms, perceived life stress, and trait rumination. In summary, results showed that rumination after stress predicted non-habituation of HPA axis responses. This finding implicates rumination as one possible mechanism mediating maladaptive stress response patterns, and it might also offer a pathway through which rumination might lead to negative health outcomes.
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影响因子：
5
作者：
COHEN, S;KAMARCK, T;MERMELSTEIN, R
通讯作者：
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