Striatopallidal neurons control avoidance behavior in exploratory tasks.
Striatopallidal neurons control avoidance behavior in exploratory tasks.
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DOI：
10.1038/s41380-018-0051-3
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发表时间：
2020-02
影响因子：
11
通讯作者：
Kravitz AV
中科院分区：
文献类型：
--
作者：
LeBlanc KH;London TD;Szczot I;Bocarsly ME;Friend DM;Nguyen KP;Mengesha MM;Rubinstein M;Alvarez VA;Kravitz AV
背侧纹状体与冲突下的决策有关，但纹状体神经元促进接近-回避冲突的机制仍不清楚。我们假设纹状体多巴胺D2受体（D2 R）表达神经元促进回避，并在小鼠的两个探索性接近-回避冲突范例中测试了这一假设：高架零迷宫和旷场。纹状体苍白球神经元（iMSN）上的D2 R基因消除，而不是其他神经群体，增加了在这两项任务中对开放区域的回避，这种方式与运动的全球变化无关。在iMSN上缺乏D2 R的小鼠中，背内侧iMSN的群体钙活性被破坏，这表明iMSN的中断输出有助于提高回避行为。一致地，用光遗传学刺激人工破坏iMSN输出提高了对这些任务的开放区域的回避，而抑制iMSN输出减少了回避。我们的结论是，背内侧纹状体iMSNs控制接近回避冲突的探索性任务，并强调这一神经人口作为一个潜在的目标，减少回避焦虑症。
The dorsal striatum has been linked to decision-making under conflict, but the mechanism by which striatal neurons contribute to approach-avoidance conflicts remains unclear. We hypothesized that striatopallidal dopamine D2 receptor (D2R)-expressing neurons promote avoidance, and tested this hypothesis in two exploratory approach-avoidance conflict paradigms in mice: the elevated zero maze and open field. Genetic elimination of D2Rs on striatopallidal neurons (iMSNs), but not other neural populations, increased avoidance of the open areas in both tasks, in a manner that was dissociable from global changes in movement. Population calcium activity of dorsomedial iMSNs was disrupted in mice lacking D2Rs on iMSNs, suggesting that disrupted output of iMSNs contributes to heightened avoidance behavior. Consistently, artificial disruption of iMSN output with optogenetic stimulation heightened avoidance of open areas of these tasks, while inhibition of iMSN output reduced avoidance. We conclude that dorsomedial striatal iMSNs control approach-avoidance conflicts in exploratory tasks, and highlight this neural population as a potential target for reducing avoidance in anxiety disorders.
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影响因子：
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作者：
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Bach DR
影响因子：
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