Cerebral vascular control is associated with skeletal muscle pH in chronic fatigue syndrome patients both at rest and during dynamic stimulation.
Cerebral vascular control is associated with skeletal muscle pH in chronic fatigue syndrome patients both at rest and during dynamic stimulation.
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DOI：
10.1016/j.nicl.2012.12.006
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发表时间：
2013
影响因子：
4.2
通讯作者：
Blamire, Andrew M.
中科院分区：
文献类型：
--
作者：
He, Jiabao;Hollingsworth, Kieren G.;Newton, Julia L.;Blamire, Andrew M.
关键词：
脑血流（CBF）通过脑血管控制而维持，尽管全身血压发生变化，但这种严格的调节被认为是在局部组织控制下进行的。慢性疲劳综合征（CFS）与多种症状相关，包括直立性不耐受、骨骼肌pH值异常和认知障碍。已知CFS患者CBF减少，直立性不耐受与血管调节异常有关，而骨骼肌pH异常与自主神经功能障碍有关。这些发现表明自主神经功能障碍是CFS的中心特征，脑血管控制受到脑外因素的影响，这是一种影响区域调节稳定性的宏观力量。因此，我们探讨了CFS中脑血管控制和骨骼肌pH值管理之间是否存在生理联系。从我们当地的CFS临床服务处连续招募了17例符合Fukuda标准的CFS患者。为了探测静态情况，在静息时使用MRI和31P磁共振波谱（31P- mrs）测量CBF和骨骼肌pH。为了检查动态控制，在Valsalva运动（一种标准的自主神经功能挑战）同时进行脑功能MRI，而在足底弯曲运动期间进行31P-MRS。CBF与静息时骨骼肌pH呈显著负相关（r = - 0.67, p < 0.01）。VM交感期脑血管收缩时间延长与足底屈曲运动后骨骼肌pH升高相关（r = 0.69, p < 0.008）。综上所述，无论是静止状态还是动态刺激后，CFS的脑血管控制都与骨骼肌pH密切相关。慢性疲劳综合症的脑血管控制受到脑外因素的影响。功能磁共振成像（fMRI）探测脑血管控制时进行的Valsalva动作。慢性疲劳综合症患者静息时脑血流与骨骼肌pH值有关。脑血管控制与慢性疲劳综合症刺激后骨骼pH值恢复有关。我们的研究结果指向慢性疲劳综合症的外围或全身病因。
Cerebral blood flow (CBF) is maintained despite changing systemic blood pressure through cerebral vascular control, with such tight regulation believed to be under local tissue control. Chronic fatigue syndrome (CFS) associates with a wide range of symptoms, including orthostatic intolerance, skeletal muscle pH abnormalities and cognitive impairment. CFS patients are known to have reduced CBF and orthostatic intolerance associates with abnormal vascular regulation, while skeletal muscle pH abnormalities associate with autonomic dysfunction. These findings point to autonomic dysfunction as the central feature of CFS, and cerebral vascular control being influenced by factors outside of the brain, a macroscopic force affecting the stability of regional regulation. We therefore explored whether there was a physiological link between cerebral vascular control and skeletal muscle pH management in CFS. Seventeen consecutive CFS patients fulfilling the Fukuda criteria were recruited from our local CFS clinical service. To probe the static scenario, CBF and skeletal muscle pH were measured at rest using MRI and 31P magnetic resonance spectroscopy (31P-MRS). To examine dynamic control, brain functional MRI was performed concurrently with Valsalva manoeuvre (VM), a standard autonomic function challenge, while 31P-MRS was performed during plantar flexion exercise. Significant inverse correlation was seen between CBF and skeletal muscle pH at rest (r = − 0.67, p < 0.01). Prolonged cerebral vascular constriction during the sympathetic phase of VM was associated with higher pH in skeletal muscle after plantar flexion exercise (r = 0.69, p < 0.008). In conclusion, cerebral vascular control is closely related to skeletal muscle pH both at rest and after dynamic stimulation in CFS. ► Cerebral vascular control in CFS is affected by factors external to the brain. ► Valsalva manoeuvre performed during fMRI probes cerebral vascular control. ► Cerebral blood flow is associated with skeletal muscle pH at rest in CFS. ► Cerebral vascular control relates to skeletal pH recovery after stimulation in CFS. ► Our results point towards a peripheral or systemic cause for CFS.
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影响因子：
12.6
作者：
Hollingsworth, Kieren G.;Newton, Julia L.;Jones, David E. J.
通讯作者：
Jones, David E. J.
影响因子：
4.4
作者：
Biswal, Bharat;Kunwar, Pratap;Natelson, Benjamin H.
通讯作者：
Natelson, Benjamin H.
影响因子：
4.1
作者：
Bogaerts, Katleen;Hubin, Morgane;Van den Bergh, Omer
通讯作者：
Van den Bergh, Omer
影响因子：
13.3
作者：
Newton, J. L.;Okonkwo, O.;Jones, D. E. J.
通讯作者：
Jones, D. E. J.
DOI：
10.1111/j.1365-2362.2010.02310.x
发表时间：
2010-07-01
影响因子：
5.5
作者：
Hollingsworth, Kieren G.;Jones, David E. J.;Newton, Julia L.
通讯作者：
Newton, Julia L.