Dendritic spikes enhance stimulus selectivity in cortical neurons in vivo.
Dendritic spikes enhance stimulus selectivity in cortical neurons in vivo.
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DOI：
10.1038/nature12600
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发表时间：
2013-11-07
期刊：
影响因子：
64.8
通讯作者：
Häusser M
中科院分区：
文献类型：
--
作者：
Smith SL;Smith IT;Branco T;Häusser M
神经元树突是可电兴奋的：它们可以在足够强的突触输入下产生再生事件，如树突尖峰。虽然在许多类型的神经元中已经观察到了这样的事件，但活性树突如何在体内调节神经元的输出还不是很清楚。在这里，我们通过在轻度麻醉和清醒的小鼠的感觉处理过程中直接从初级视觉皮质锥体神经元的树突进行膜片钳记录来解决这个问题。视觉刺激触发了包括树突棘波在内的再生事件。这些事件被定向调节，并被超极化或细胞内NMDA受体阻断所抑制。这两种操作也降低了在胞体测量的亚阈值定向调节的选择性，从而将树突再生事件与躯体定向调节联系起来。综上所述，我们的结果表明，由视觉输入触发的树突棘波有助于一项基本的皮质计算：增强视觉皮质的定向选择性。
Neuronal dendrites are electrically excitable: they can generate regenerative events such as dendritic spikes in response to sufficiently strong synaptic input. Although such events have been observed in many neuronal types, how active dendrites contribute to tuning of neuronal output in vivo is not well understood. Here we have addressed this question by performing direct patch-clamp recordings from the dendrites of pyramidal neurons in primary visual cortex during sensory processing in lightly anesthetized and awake mice. Visual stimulation triggered regenerative events that included dendritic spikes. These events were orientation tuned and suppressed by either hyperpolarization or intracellular NMDA receptor blockade. Both of these manipulations also decreased the selectivity of subthreshold orientation tuning measured at the soma, thus linking dendritic regenerative events with somatic orientation tuning. Together, our results suggest that dendritic spikes triggered by visual input contribute to a fundamental cortical computation: enhancing orientation selectivity in visual cortex.
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影响因子：
3.9
作者：
Pologruto, Thomas A.;Sabatini, Bernardo L.;Svoboda, Karel
通讯作者：
Svoboda, Karel
DOI：
10.1126/science.1189664
发表时间：
2010-09-24
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Branco T;Clark BA;Häusser M
通讯作者：
Häusser M
影响因子：
--
作者：
Pelli, DG
通讯作者：
Pelli, DG
影响因子：
64.8
作者：
HIRSCH, JA;ALONSO, JM;REID, RC
通讯作者：
REID, RC
影响因子：
64.8
作者：
Schiller, J;Major, G;Schiller, Y
通讯作者：
Schiller, Y