Activation of CD4 cells by fibronectin and anti-CD3 antibody. A synergistic effect mediated by the VLA-5 fibronectin receptor complex.
Activation of CD4 cells by fibronectin and anti-CD3 antibody. A synergistic effect mediated by the VLA-5 fibronectin receptor complex.
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DOI：
10.1084/jem.170.4.1133
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发表时间：
1989-10-01
期刊：
影响因子：
--
通讯作者：
Morimoto C
中科院分区：
文献类型：
--
作者：
Matsuyama T;Yamada A;Kay J;Yamada KM;Akiyama SK;Schlossman SF;Morimoto C
In this study, fibronectin synergized with anti-CD3 antibody to promote CD4 cell proliferation in a serum-free culture system. The cell- adhesive domain plus additional regions of the fibronectin molecule are involved in this synergy. Anti4B4(CDw29) antibody blocked the activation of CD4 cells in this system. Furthermore, it is the VLA-5 protein within the set of molecules recognized by anti-4B4 that serves as a fibronectin receptor on the CD4 lymphocytes. The VLA-5 fibronectin receptor was mainly expressed on CD4+ CD45R-CDw29+ cells and may in part contribute to the unique function of these cells.
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影响因子：
64.5
作者：
OBARA, M;KANG, MS;YAMADA, KM
通讯作者：
YAMADA, KM
影响因子：
15.9
作者：
MORIMOTO, C;REINHERZ, EL;SCHLOSSMAN, SF
通讯作者：
SCHLOSSMAN, SF
影响因子：
64.8
作者：
LAEMMLI, UK
通讯作者：
LAEMMLI, UK
DOI：
10.1073/pnas.83.3.752
发表时间：
1986-02-01
影响因子：
11.1
作者：
COSGROVE, LJ;SANDRIN, MS;MCKENZIE, IFC
通讯作者：
MCKENZIE, IFC
影响因子：
15.3
作者：
ALITALO, K;HOVI, T;VAHERI, A
通讯作者：
VAHERI, A