Relationship between amounts of daily cigarette consumption and abdominal obesity moderated by CYP2A6 genotypes in Chinese male current smokers.
Relationship between amounts of daily cigarette consumption and abdominal obesity moderated by CYP2A6 genotypes in Chinese male current smokers.
复制标题
DOI：
10.1007/s12160-011-9318-5
复制
发表时间：
2012-04
期刊：
影响因子：
--
通讯作者：
Chen WQ
中科院分区：
文献类型：
--
作者：
Liu T;David SP;Tyndale RF;Wang H;Yu XQ;Chen W;Zhou Q;Chen WQ
吸烟是腹部肥胖的一个重要危险因素。然而，CYP 2A 6基因型在多大程度上调节吸烟和腹型肥胖之间的关系尚未确定。本研究旨在探讨吸烟量与腹型肥胖的关系是否受CYP 2A 6基因型的影响。954名男性吸烟者被选中。采集静脉标本检测血清可替宁和CYP 2A 6基因型，并将所有吸烟者分为重度吸烟者（>15支/d）和轻度吸烟者（≤15支/d）。与轻度吸烟相比，重度吸烟增加了腹部肥胖的风险（比值比（OR）=1.57; 95%CI，1.13-2.19）。此外，重度吸烟与CYP 2A 6弱代谢型基因型对腹型肥胖有正交互作用（OR=3.90; 95% CI，1.25 ~ 12.18）。此外，CYP 2A 6弱代谢型基因型与尼古丁代谢较慢相关。大量吸烟可能会增加腹部肥胖的风险，特别是在CYP 2A 6弱代谢基因型吸烟者中。
Cigarette smoking is an important risk factor for abdominal obesity. However, the degree to which the CYP2A6 genotype moderates the relationship between smoking and abdominal obesity has not been established. This study aims to investigate whether or not the relationship between smoking quantity and abdominal obesity is influenced by CYP2A6 genotypes. Nine hundred fifty-four male current smokers were selected. A venous specimen was collected to test serum cotinine and CYP2A6 genotype, and all smokers were divided into heavy (>15 cigarettes/day) and light smokers (≤15 cigarettes/day). Heavy smoking increased the risk of abdominal obesity (odds ratio (OR)=1.57; 95% CI, 1.13–2.19) compared with light smoking. Furthermore, heavy smoking had a positive interactive effect with CYP2A6 poor metabolizer genotype on abdominal obesity (OR=3.90; 95% CI, 1.25– 12.18). Moreover, CYP2A6 poor metabolizer genotypes were associated with slower nicotine metabolism. Heavy smoking may increase the risk of abdominal obesity—particularly in smokers with CYP2A6 poor metabolizer genotypes.
登录
查看更多内容
DOI：
10.1111/j.1360-0443.2010.03353.x
发表时间：
2011-05
期刊：
Addiction (Abingdon, England)
影响因子：
--
作者：
Liu T;David SP;Tyndale RF;Wang H;Zhou Q;Ding P;He YH;Yu XQ;Chen W;Crump C;Wen XZ;Chen WQ
通讯作者：
Chen WQ
影响因子：
2.1
作者：
Nakajima, Miki;Yokoi, Tsuyoshi
通讯作者：
Yokoi, Tsuyoshi
影响因子：
4.9
作者：
Bamia, C;Trichopoulou, A;Trichopoulos, D
通讯作者：
Trichopoulos, D
影响因子：
2.6
作者：
Mwenifumbo, JC;Myers, MG;Tyndale, RF
通讯作者：
Tyndale, RF
影响因子：
2.6
作者：
Ho, Man Ki;Mwenifumbo, Jill C.;Tyndale, Rachel F.
通讯作者：
Tyndale, Rachel F.