Gammaherpesvirus and lymphoproliferative disorders in immunocompromised patients.
Gammaherpesvirus and lymphoproliferative disorders in immunocompromised patients.
复制标题
免疫功能低下的患者中的γ掌病毒和淋巴增生性疾病。
DOI：
10.1016/j.canlet.2011.03.003
复制
发表时间：
2011-06-28
期刊：
影响因子：
9.7
通讯作者：
Cesarman, Ethel
中科院分区：
文献类型：
--
作者：
Cesarman, Ethel
两种亲淋巴性人γ疱疹病毒可引起淋巴组织增生性疾病：爱泼斯坦巴尔病毒（EBV，正式命名为人疱疹病毒4）和卡波西肉瘤疱疹病毒（KSHV，也称为人疱疹病毒8）。患有遗传性或获得性免疫缺陷的个体发生由这两种病毒之一引起的恶性肿瘤的风险大大增加。特定类型的淋巴组织增生，包括恶性淋巴瘤，发生在HIV感染者、移植受者和原发性免疫缺陷儿童中。这些疾病中的一些，如霍奇金淋巴瘤和非霍奇金淋巴瘤类似于免疫功能正常的患者中发生的疾病，但存在EBV的肿瘤比例增加。其他如原发性渗出性淋巴瘤和多形移植后淋巴组织增生性疾病，在特定的免疫缺陷状态之外很少见。了解特定的病毒协会在选定的淋巴组织增生性疾病，和病毒肿瘤发生的分子机制的分子见解，将导致更好的治疗这些经常破坏性的疾病。
Two lymphotropic human gamma herpesviruses can cause lymphoproliferative disorders: Epstein Barr virus (EBV, formally designated as human herpesvirus 4) and Kaposi sarcoma herpesvirus (KSHV, also called human herpesvirus 8). Individuals with inherited or acquired immunodeficiency have a greatly increased risk of developing a malignancy caused by one of these two viruses. Specific types of lymphoproliferations, including malignant lymphomas, occur in individuals with HIV infection, transplant recipients and children with primary immunodeficiency. Some of these diseases, such as Hodgkin and nonHodgkin lymphoma resemble those occurring in immunocompetent patients, but the proportion of tumors in which EBV is present is increased. Others, like primary effusion lymphoma and polymorphic post-transplant lymphoproliferative disorder are rarely seen outside the context of a specific immunodeficient state. Understanding the specific viral associations in selected lymphoproliferative disorders, and the molecular insights into the molecular mechanisms of viral oncogenesis, will lead to better treatments for these frequently devastating diseases.
登录
查看更多内容
影响因子：
4.1
作者：
Carbone, Antonino;Gloghini, Annunziata;Spina, Michele
通讯作者：
Spina, Michele
影响因子：
5.4
作者：
Brinkmann, MM;Glenn, M;Schulz, TF
通讯作者：
Schulz, TF
影响因子：
3.3
作者：
Brousset, P;Cesarman, E;Delsol, G
通讯作者：
Delsol, G
影响因子：
5.4
作者：
Brown, HJ;Song, MJ;Sun, R
通讯作者：
Sun, R
影响因子：
20.3
作者：
Cesarman, E;Chadburn, A;Knowles, DM
通讯作者：
Knowles, DM