Expression of VPAC1 in a murine model of allergic asthma.
Expression of VPAC1 in a murine model of allergic asthma.
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DOI：
10.1186/1745-6673-8-28
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发表时间：
2013-10-10
期刊：
影响因子：
--
通讯作者：
Groneberg DA
中科院分区：
文献类型：
--
作者：
Lauenstein HD;Quarcoo D;Welte T;Braun A;Groneberg DA
Vasoactive intestinal polypeptide (VIP) is a putative neurotransmitter of the inhibitory non-adrenergic non-cholinergic nervous system and influences the mammalian airway function in various ways. Hence known for bronchodilatory, immunomodulatory and mucus secretion modulating effects by interacting with the VIP receptors VPAC1 and VPAC2, it is discussed to be a promising target for pharmaceutical intervention in common diseases such as COPD and bronchial asthma. Here we examined the expression and transcriptional regulation of VPAC1 in the lungs of allergic mice using an ovalbumin (OVA) -induced model of allergic asthma. Mice were sensitized to OVA and challenged with an OVA aerosol. In parallel a control group was sham sensitized with saline. VPAC1 expression was examined using RT-PCR and real time-PCR studies were performed to quantify gene transcription. VPAC1 mRNA expression was detected in all samples of OVA-sensitized and challenged animals and control tissues. Further realtime analysis did not show significant differences at the transcriptional level. Although the present studies did not indicate a major transcriptional regulation of VPAC1 in states of allergic airway inflammation, immunomodulatory effects of VPAC1 might still be present due to regulations at the translational level.
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DOI：
10.1186/1745-6673-8-15
发表时间：
2013-05-24
期刊：
Journal of occupational medicine and toxicology (London, England)
影响因子：
--
作者：
Baur X
通讯作者：
Baur X
影响因子：
4.4
作者：
Delgado, M;Ganea, D
通讯作者：
Ganea, D
影响因子：
5
作者：
Eynott, PR;Groneberg, DA;Chung, KF
通讯作者：
Chung, KF
DOI：
10.1186/1745-6673-6-23
发表时间：
2011-08-14
期刊：
Journal of occupational medicine and toxicology (London, England)
影响因子：
--
作者：
Alexopoulos EC;Bouros D;Dimadi M;Serbescu A;Bakoyannis G;Kokkinis FP
通讯作者：
Kokkinis FP
影响因子：
6.1
作者：
de Vries, A.;Engels, F.;Fischer, A.
通讯作者：
Fischer, A.