Epigenetic Aging and Immune Senescence in Women With Insomnia Symptoms: Findings From the Women's Health Initiative Study.
Epigenetic Aging and Immune Senescence in Women With Insomnia Symptoms: Findings From the Women's Health Initiative Study.
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有失眠症状的女性的表观遗传衰老和免疫衰老：女性健康倡议研究的结果。
DOI：
10.1016/j.biopsych.2016.07.008
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发表时间：
2017-01-15
影响因子：
10.6
通讯作者：
Horvath S
中科院分区：
文献类型：
--
作者：
Carroll JE;Irwin MR;Levine M;Seeman TE;Absher D;Assimes T;Horvath S
失眠症状与易患与年龄相关的发病率和死亡率有关。横断面数据表明，加速的生物衰老可能是睡眠影响风险的机制。一种利用表观遗传甲基化DNA来确定年龄加速的新方法已经证明了作为表观遗传时钟和预测年龄相关发病率和死亡率的预测效用。在妇女健康倡议（WHI）研究中，我们研究了表观遗传年龄和免疫细胞老化与睡眠的关系(N= 2078；年龄M(SD)=64.5(7.1))，评估失眠症状（不安、入睡困难、夜间醒来、难以入睡和早醒）、睡眠时间（短睡5小时或更少；长睡80小时）、表观遗传年龄、naïve T细胞（CD8+CD45RA+CCR7+）和晚期分化T细胞（CD8+CD28−CD45RA−）。失眠症状与晚表观遗传年龄相关，B(SE)=1.02（p < 0.05）。37)，经协变量调整后P=0.005。失眠症状也与晚期分化T细胞增多有关（B(SE)= 0.59）。21)， P=.006)，但与naïve T细胞无关。自我报告的睡眠时间长短与表观遗传年龄无关。短睡眠与naïve T细胞减少相关（P< 0.005），而长睡眠与naïve T细胞减少无关（P< 0.05），两者都与晚期分化T细胞无关。失眠症状与血液组织表观遗传年龄增加有关，并与晚期分化CD8+ T细胞计数增高有关。短睡眠与表观遗传年龄和晚期分化细胞计数无关，但与naïve T细胞的下降有关。在这项针对美国女性的大规模人口研究中，失眠症状与加速衰老有关。
Insomnia symptoms are associated with vulnerability to age-related morbidity and mortality. Cross-sectional data suggest accelerated biological aging may be a mechanism through which sleep influences risk. A novel method for determining age acceleration using epigenetic methylation to DNA has demonstrated predictive utility as an epigenetic clock and prognostic of age-related morbidity and mortality. We examined the association of epigenetic age and immune cell aging with sleep in the Women’s Health Initiative (WHI) study (N=2,078; Age M(SD)=64.5(7.1) with assessment of insomnia symptoms (restlessness, difficulty falling asleep, waking at night, trouble getting back to sleep, and early awakenings), sleep duration (short-sleep 5 or less; long-sleep >8hrs), epigenetic age, naïve T cell (CD8+CD45RA+CCR7+), and late differentiated T cells (CD8+CD28−CD45RA−). Insomnia symptoms were related to advanced epigenetic age, B(SE)=1.02(.37), P=0.005, after adjustments for covariates. Insomnia symptoms were also associated with more late differentiated T cells (B(SE)=.59(.21), P=.006), but not with naïve T cells. Self-reported short and long sleep duration were unrelated to epigenetic age. Short sleep, but not long sleep, was associated with fewer naïve T cells (P<.005) and neither were related to late differentiated T cells. Symptoms of insomnia were associated with increased epigenetic age of blood tissue, and were associated with higher counts of late differentiated CD8+ T cells. Short sleep was unrelated to epigenetic age and late differentiated cell counts, but was related to a decline in naïve T cells. In this large population based study of women in the United States, insomnia symptoms are implicated in accelerated aging.
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影响因子：
3.7
作者：
Carroll, Judith E.;Seeman, Teresa E.;Olmstead, Richard;Melendez, Gerson;Sadakane, Ryan;Bootzin, Richard;Nicassio, Perry;Irwin, Michael R.
通讯作者：
Irwin, Michael R.
影响因子：
3.7
作者：
Bocklandt S;Lin W;Sehl ME;Sánchez FJ;Sinsheimer JS;Horvath S;Vilain E
通讯作者：
Vilain E
全基因组甲基化谱揭示了人类衰老速度的定量观点。
影响因子：
16
作者：
Hannum, Gregory;Guinney, Justin;Zhao, Ling;Zhang, Li;Hughes, Guy;Sadda, SriniVas;Klotzle, Brandy;Bibikova, Marina;Fan, Jian-Bing;Gao, Yuan;Deconde, Rob;Chen, Menzies;Rajapakse, Indika;Friend, Stephen;Ideker, Trey;Zhang, Kang
通讯作者：
Zhang, Kang
DOI：
10.1016/j.bbi.2015.08.024
发表时间：
2016-01
期刊：
Brain, behavior, and immunity
影响因子：
--
作者：
Carroll JE;Cole SW;Seeman TE;Breen EC;Witarama T;Arevalo JMG;Ma J;Irwin MR
通讯作者：
Irwin MR
影响因子：
7.8
作者：
Bakaysa, Stephanie L.;Mucci, Lorelei A.;Pedersen, Nancy L.
通讯作者：
Pedersen, Nancy L.