A Perspective on the Structural and Functional Constraints for Immune Evasion: Insights from Influenza Virus.
A Perspective on the Structural and Functional Constraints for Immune Evasion: Insights from Influenza Virus.
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关于免疫逃避的结构和功能约束的观点：来自流感病毒的见解。
DOI：
10.1016/j.jmb.2017.06.015
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发表时间：
2017-08-18
影响因子：
5.6
通讯作者：
Wilson IA
中科院分区：
文献类型：
--
作者：
Wu NC;Wilson IA
流感病毒进化迅速，不断逃避自然免疫力。针对流感病毒的大多数体液免疫应答靶向血凝素糖蛋白（HA），其是病毒表面上的主要抗原。HA由用于受体结合的球状头域和用于膜融合的茎域组成。HA的主要抗原位点位于球状头部亚结构域，该亚结构域高度耐受氨基酸替换和糖基化位点的连续添加。尽管如此，HA上的受体结合位点（RBS）和茎区的进化受到它们分别参与宿主受体和介导膜融合的功能作用的严重限制。在这里，我们审查如何广泛中和抗体（bnAbs）利用这些进化的限制，以防止不同的流感病毒株。我们还讨论了新出现的作用，其他表位是保守的，只在病毒的子集。流感病毒的进化生物学、免疫学、结构生物学和病毒学知识的快速增长对于开发和设计更通用的流感疫苗以及新的治疗方法是非常宝贵的。
Influenza virus evolves rapidly to constantly escape from natural immunity. Most humoral immune responses to influenza virus target the hemagglutinin glycoprotein (HA), which is the major antigen on the surface of the virus. The HA is comprised of a globular head domain for receptor binding and a stem domain for membrane fusion. The major antigenic sites of HA are located in the globular head subdomain, which is highly tolerant of amino-acid substitutions and continual addition of glycosylation sites. Nonetheless, the evolution of the receptor-binding site (RBS) and the stem region on HA is severely constrained by their functional roles in engaging the host receptor and in mediating membrane fusion, respectively. Here, we review how broadly neutralizing antibodies (bnAbs) exploit these evolutionary constraints to protect against diverse influenza strains. We also discuss the emerging role of other epitopes that are conserved only in subsets of viruses. This rapidly increasing knowledge of the evolutionary biology, immunology, structural biology, and virology of influenza virus is invaluable for development and design of more universal influenza vaccines as well as novel therapeutics.
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影响因子：
3.7
作者：
Ding H;Tsai C;Zhou F;Buchy P;Deubel V;Zhou P
通讯作者：
Zhou P
影响因子：
17.1
作者：
Andrews SF;Huang Y;Kaur K;Popova LI;Ho IY;Pauli NT;Henry Dunand CJ;Taylor WM;Lim S;Huang M;Qu X;Lee JH;Salgado-Ferrer M;Krammer F;Palese P;Wrammert J;Ahmed R;Wilson PC
通讯作者：
Wilson PC
影响因子：
10.7
作者：
Bhatt, Samir;Holmes, Edward C.;Pybus, Oliver G.
通讯作者：
Pybus, Oliver G.
影响因子：
5.4
作者：
Bommakanti, Gayathri;Lu, Xianghan;Liang, Xiaoping
通讯作者：
Liang, Xiaoping
DOI：
10.1098/rstb.1989.0028
发表时间：
1989-06-12
影响因子：
6.3
作者：
COLMAN, PM;TULIP, WR;WEBSTER, RG
通讯作者：
WEBSTER, RG