The Elusive Origin of Atherosclerotic Plaque Calcification.
The Elusive Origin of Atherosclerotic Plaque Calcification.
复制标题
DOI：
10.3389/fcell.2021.622736
复制
发表时间：
2021
影响因子：
5.5
通讯作者：
Magne D
中科院分区：
文献类型：
--
作者：
Canet-Soulas E;Bessueille L;Mechtouff L;Magne D
几十年甚至几个世纪以来，人们就知道动脉会随着年龄的增长而钙化。血管钙化可能影响所有成年人，因为几乎所有人都有动脉粥样硬化斑块：脂质、炎症细胞、坏死性碎片和磷酸钙晶体的堆积。高血管钙评分与高心血管死亡风险相关，相对较新的数据表明，即使是在早期斑块中形成的微钙化也可能破坏斑块的稳定性，并引发心血管事件。如果说斑块钙化的细胞和分子机制在小鼠身上表现得相对较好，那么人类斑块似乎是通过不同的机制钙化的，这些机制仍然不清楚。在此背景下，我们将首先回顾关于人类斑块中早期钙化的位置和特征的文章，然后回顾探索人类和小鼠斑块钙化机制的文章。
It has been known for decades or even centuries that arteries calcify as they age. Vascular calcification probably affects all adults, since virtually all have atherosclerotic plaques: an accumulation of lipids, inflammatory cells, necrotic debris, and calcium phosphate crystals. A high vascular calcium score is associated with a high cardiovascular mortality risk, and relatively recent data suggest that even microcalcifications that form in early plaques may destabilize plaques and trigger a cardiovascular event. If the cellular and molecular mechanisms of plaque calcification have been relatively well characterized in mice, human plaques appear to calcify through different mechanisms that remain obscure. In this context, we will first review articles reporting the location and features of early calcifications in human plaques and then review the articles that explored the mechanisms though which human and mouse plaques calcify.
登录
查看更多内容
影响因子：
13.6
作者：
Antonioli L;Pacher P;Vizi ES;Haskó G
通讯作者：
Haskó G
影响因子：
20.1
作者：
Dweck MR;Aikawa E;Newby DE;Tarkin JM;Rudd JH;Narula J;Fayad ZA
通讯作者：
Fayad ZA
影响因子：
5.3
作者：
Bobryshev YV;Killingsworth MC;Lord RS;Grabs AJ
通讯作者：
Grabs AJ
影响因子：
5.3
作者：
Bhaskar, Vinay;Yin, Johnny;Kantak, Seema S.
通讯作者：
Kantak, Seema S.
影响因子：
4.8
作者：
Byon, Chang Hyun;Javed, Amjad;Chen, Yabing
通讯作者：
Chen, Yabing