The aerolysin nanopore: from peptidomic to genomic applications.
The aerolysin nanopore: from peptidomic to genomic applications.
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DOI:
10.1039/c8nr04255a
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发表时间:
2018-08-07
期刊:
影响因子:
6.7
通讯作者:
Tian K
中科院分区:
文献类型:
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作者:
Wang Y;Gu LQ;Tian K
The aerolysin pore (ARP) is a newly emerging nanopore that has been extensively used for peptide and protein sensing. Recently, several groups have explored the application of ARP in detecting genetic and epigenetic markers. This brief review summarizes the current applications of ARP, progressing from peptidomic to genomic detection; the recently reported site-directed mutagenesis of ARP; and new genomic DNA sensing approaches, and their advantages and disadvantages. This review will also discuss the perspectives and future applications of ARP for nucleic acid sequencing and biomolecule sensing.
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