p53 protein expression and its prognostic importance in patients with nodal non-Hodgkin's lymphoma.
p53 protein expression and its prognostic importance in patients with nodal non-Hodgkin's lymphoma.
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DOI：
10.3346/jkms.2000.15.1.59
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发表时间：
2000-02
影响因子：
4.5
通讯作者：
Park CK
中科院分区：
文献类型：
--
作者：
Ahn MJ;Kim H;Kim IS;Park JK;Ki MR;Park CK
为了确定p53蛋白表达是否可以作为预测淋巴结非霍奇金淋巴瘤（NHL）治疗反应和总生存率的指标，我们分析了69例NHL患者的p53蛋白表达。采用免疫组化法检测p53蛋白表达，并随访1-148个月（中位时间12.2个月）。p53蛋白阳性率为33.3%（23/69）。全身化疗的完全缓解率与分期（I/II）相关（p=0.038），但与p53表达无关（p=0.2856）。总生存率差与分期（p=0.0010）或IPI评分（p=0.0076）相关，但与p53表达无关（p=0.8601）。根据分期分层分析，在III/IV期患者中，p53阳性组的总生存率比p53阴性组低。多变量分析显示，p53阳性组与较低的CR率相比，p53阴性组（p=0.046），而总生存期与阶段（p=0.0320），而不是与p53状态。p53表达与DLBL患者CR率低相关。细胞周期调控因子p53在NHL中的预后价值有待于进一步的大样本和同质性NHL研究。
To determine whether the p53 expression might be a predictor for treatment response and overall survival in nodal non-Hodgkin's lymphoma (NHL), we analyzed the expression of p53 in 69 NHL patients. p53 protein expression was analyzed by immunohistochemistry with long-term follow up (1-148 months: median 12.2). p53 expression was noted in 23/69 (33.3%) patients. Complete response (CR) rate to systemic chemotherapy was correlated with stage (I/II) (p=0.038), but not with p53 expression (p=0.2856). Poor overall survival was associated with stage (p=0.0010) or IPI score (p=0.0076), but not with p53 expression (p=0.8601). From stratification analysis by stage, in stage III/IV patients, the p53 positive group had a trend to be associated with poor overall survival than the p53 negative group. Multivariate analysis revealed that p53 positive group was associated with less CR rate compared to the p53 negative group (p=0.046), whereas overall survival was correlated with stage (p=0.0320), not with p53 status. p53 expression was associated with less CR rate in patients with DLBL. Further studies with large numbers of samples and homogenous group of NHL are needed to determine the prognostic value of cell cycle regulator, p53 in NHL.
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