PART 2: Mouse models for multiple sclerosis research.
PART 2: Mouse models for multiple sclerosis research.
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DOI：
10.1002/nau.24654
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发表时间：
2021-04
影响因子：
2
通讯作者：
Smith PP
中科院分区：
文献类型：
--
作者：
Ramasamy R;Smith PP
下尿路症状和功能障碍（LUTS/LUTD）导致大多数多发性硬化症（MS）患者生活质量下降、发病率和医疗干预需求。虽然MS是一种炎性神经退行性疾病，但传统上将包括神经元控制障碍在内的临床表现归因于神经退行性疾病导致的神经信号传导丧失。MS-LUTS/LUTD的临床方法集中在尿动力学功能障碍的背景下解决症状，因为病理生理学理解不完整。小鼠模型为发现该疾病及其临床表现的更详细的分子、细胞和组织水平知识提供了有用的研究平台。这两部分审查的目的是提供一个国家的最先进的更新使用的小鼠模型多发性硬化症的研究，重点是下尿路症状。第一部分总结了目前对MS病理生理学的理解，对下尿路症状的影响，并简要介绍了可用于研究MS的小鼠模型的类型。第二部分介绍了目前可用于研究MS的常见动物模型，其机制，与MS-LUTS/LUTD的相关性及其泌尿病理生理学，优点和缺点。
Lower urinary tract symptoms and dysfunction (LUTS/LUTD) contribute to loss of quality of life, morbidity, and need for medical intervention in most patients with Multiple Sclerosis (MS). Although MS is an inflammatory neurodegenerative disease, clinical manifestations including continence control disorders have traditionally been attributed to loss of neural signaling due to neurodegeneration. Clinical approaches to MS-LUTS/LUTD have focused on addressing symptoms in the context of urodynamic dysfunctions as pathophysiologic understandings are incomplete. The mouse model provides a useful research platform for discovery of more detailed molecular, cellular, and tissue-level knowledge of the disease and its clinical manifestations. The aim of this two-part review is to provide a state-of-the-art update on the use of the mouse model for multiple sclerosis research, with a focus on lower urinary tract symptoms. Part I presents a summary of current understanding of MS pathophysiology, the impact on lower urinary tract symptoms, and briefly introduces the types of mouse models available to study MS. Part II presents the common animal models that are currently available to study MS, their mechanism, relevance to MS-LUTS/LUTD and their urinary pathophysiology, advantages and disadvantages.
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影响因子：
11.2
作者：
Chang, Ansi;Staugaitis, Susan M.;Dutta, Ranjan;Batt, Courtney E.;Easley, Kathryn E.;Chomyk, Anthony M.;Yong, V. Wee;Fox, Robert J.;Kidd, Grahame J.;Trapp, Bruce D.
通讯作者：
Trapp, Bruce D.
影响因子：
5.8
作者：
Borello-France, D;Leng, W;Cannon, TW
通讯作者：
Cannon, TW
影响因子：
11
作者：
BETTS, CD;DMELLOW, MT;FOWLER, CJ
通讯作者：
FOWLER, CJ
DOI：
10.1177/1352458509104594
发表时间：
2009-07-01
期刊：
MULTIPLE SCLEROSIS
影响因子：
--
作者：
Al-Izki, S.;Pryce, G.;Baker, D.
通讯作者：
Baker, D.
影响因子：
6.4
作者：
Albert, Monika;Antel, Jack;Stadelmann, Christine
通讯作者：
Stadelmann, Christine