Musculoskeletal disorders in chronic obstructive pulmonary disease.

Musculoskeletal disorders in chronic obstructive pulmonary disease.
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DOI:
10.1155/2014/965764
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发表时间:
2014
影响因子:
--
通讯作者:
Gayan-Ramirez G
Gayan-Ramirez G
中科院分区:
生物学3区
文献类型:
--
作者:
Cielen N;Maes K;Gayan-Ramirez G

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慢性阻塞性肺疾病(COPD)是一种以呼吸道阻塞和炎症为特征的肺部疾病,但也伴随着一些肺外后果,如骨骼肌无力和骨质疏松。骨骼肌无力是一个主要的问题,因为它导致功能能力低下,健康状况受损,医疗保健利用率增加,甚至死亡,独立于肺功能。骨质疏松症会导致骨折,并与死亡率增加、功能下降、生活质量下降和需要住院治疗有关。因此,这些合并症的存在将对COPD患者的日常生活产生负面影响。在这篇综述中,我们将重点介绍这两种并存疾病、它们在COPD中的患病率、合并危险因素和发病机制。我们将试图证明这些共病的聚集性,并讨论可能的预防或治疗策略。
Chronic obstructive pulmonary disease (COPD) is a lung disease characterized by airway obstruction and inflammation but also accompanied by several extrapulmonary consequences, such as skeletal muscle weakness and osteoporosis. Skeletal muscle weakness is of major concern, since it leads to poor functional capacity, impaired health status, increased healthcare utilization, and even mortality, independently of lung function. Osteoporosis leads to fractures and is associated with increased mortality, functional decline, loss of quality of life, and need for institutionalization. Therefore, the presence of the combination of these comorbidities will have a negative impact on daily life in patients with COPD. In this review, we will focus on these two comorbidities, their prevalence in COPD, combined risk factors, and pathogenesis. We will try to prove the clustering of these comorbidities and discuss possible preventive or therapeutic strategies.
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