Preclinical Murine Models for Lung Cancer: Clinical Trial Applications.
Preclinical Murine Models for Lung Cancer: Clinical Trial Applications.
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DOI：
10.1155/2015/621324
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发表时间：
2015
影响因子：
--
通讯作者：
Morris D
中科院分区：
文献类型：
--
作者：
Kellar A;Egan C;Morris D
研究肺癌的小鼠模型历来是支持早期人类临床试验的初步临床前数据的支柱。然而，多个实验系统的可用性导致了关于哪种模型(如果有的话)最适合特定治疗策略的争论。这些模型必须准确地预测治疗的临床益处。该综述概述了目前用于研究肺癌的小鼠模型以及每种模型的优点和局限性，并对每种模型在预测治疗的临床益处方面的应用进行了回顾评估。更好地了解小鼠模型及其用途，以及它们的局限性，可能有助于未来有关肺癌新靶向治疗和化疗药物的开发和实施的研究。
Murine models for the study of lung cancer have historically been the backbone of preliminary preclinical data to support early human clinical trials. However, the availability of multiple experimental systems leads to debate concerning which model, if any, is best suited for a particular therapeutic strategy. It is imperative that these models accurately predict clinical benefit of therapy. This review provides an overview of the current murine models used to study lung cancer and the advantages and limitations of each model, as well as a retrospective evaluation of the uses of each model with respect to accuracy in predicting clinical benefit of therapy. A better understanding of murine models and their uses, as well as their limitations may aid future research concerning the development and implementation of new targeted therapies and chemotherapeutic agents for lung cancer.
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影响因子：
5.3
作者：
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通讯作者：
RAPP, UR
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