The interconnection between lipoprotein(a), lipoprotein(a) cholesterol and true LDL-cholesterol in the diagnosis of familial hypercholesterolemia
The interconnection between lipoprotein(a), lipoprotein(a) cholesterol and true LDL-cholesterol in the diagnosis of familial hypercholesterolemia
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脂蛋白（a）、脂蛋白（a）胆固醇和真低密度脂蛋白胆固醇在家族性高胆固醇血症诊断中的相互关系
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发表时间：
2020
影响因子：
4.4
通讯作者：
S. Tsimikas
中科院分区：
文献类型：
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作者：
C. Yeang;P. Willeit;S. Tsimikas
综述目的 30-50% 的家族性高胆固醇血症患者存在脂蛋白 (a) [Lp(a)] 水平升高。 Lp(a) 对家族性高胆固醇血症患者风险分层的贡献最近已得到认识，研究表明，如果 Lp(a) 升高，预后明显较差。然而，Lp(a) 升高在家族性高胆固醇血症诊断中的作用尚不明确或不被接受。最近的发现 家族性高胆固醇血症诊断中的一个重要混杂因素是 Lp(a) 升高的个体中 Lp(a) 上的胆固醇含量 (Lp(a)-C) 的显着贡献。由于 Lp(a)-C 已纳入所有临床 LDL-C 测量中，因此它可以对大多数临床算法中使用的家族性高胆固醇血症的胆固醇阈值诊断标准做出重大贡献。总结 在这篇综述中，我们讨论了 Lp(a)、Lp(a)-C 和正确的 LDL-C 在家族性高胆固醇血症的诊断和预后中的相互关系。准确测量正确的 LDL-C 或使用 apoB-100 和 Lp(a) 标准的未来研究可能会克服使用估计的 LDL-C 诊断伴有 Lp(a) 升高的个体的家族性高胆固醇血症的局限性。
Purpose of review Elevated levels of lipoprotein(a) [Lp(a)] are present in 30–50% of patients with familial hypercholesterolemia. The contribution of Lp(a) towards risk stratification of patients with familial hypercholesterolemia has been recently recognized, with studies showing a significantly worse prognosis if Lp(a) is elevated. However, the role of elevated Lp(a) in diagnosis of familial hypercholesterolemia is less well defined or accepted. Recent findings An important confounder in the diagnosis of familial hypercholesterolemia is the significant contribution of the cholesterol content on Lp(a) (Lp(a)-C) in individuals with elevated Lp(a). Because Lp(a)-C is incorporated into all clinical LDL-C measurements, it can contribute significantly to the cholesterol threshold diagnostic criteria for familial hypercholesterolemia used in most clinical algorithms. Summary In this review, we discuss the interrelationship of Lp(a), Lp(a)-C and correct LDL-C in the diagnosis and prognosis of familial hypercholesterolemia. Future studies of accurately measuring correct LDL-C or in using apoB-100 and Lp(a) criteria may overcome the limitations of using estimated LDL-C in the diagnosis of familial hypercholesterolemia in individuals with concomitant elevation of Lp(a).
NHLBI 工作组关于降低脂蛋白 (a) 介导的心血管疾病和主动脉瓣狭窄风险的建议。
影响因子：
24
作者：
Tsimikas S;Fazio S;Ferdinand KC;Ginsberg HN;Koschinsky ML;Marcovina SM;Moriarty PM;Rader DJ;Remaley AT;Reyes-Soffer G;Santos RD;Thanassoulis G;Witztum JL;Danthi S;Olive M;Liu L
通讯作者：
Liu L