Altered structural brain connectome in young adult fragile X premutation carriers.
Altered structural brain connectome in young adult fragile X premutation carriers.
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DOI：
10.1002/hbm.22491
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发表时间：
2014-09
影响因子：
4.8
通讯作者：
Simon, Tony J.
中科院分区：
文献类型：
--
作者：
Leow, Alex;Harvey, Danielle;Goodrich-Hunsaker, Naomi J.;Gadelkarim, Johnson;Kumar, Anand;Zhan, Liang;Rivera, Susan M.;Simon, Tony J.
Fragile X premutation carriers (fXPC) are characterized by 55–200 CGG trinucleotide repeats in the 5′ untranslated region on the Xq27.3 site of the X chromosome. Clinically, they are associated with the Fragile X-Associated Tremor/Ataxia Syndrome (FXTAS), a late-onset neurodegenerative disorder with diffuse white matter neuropathology. Here, we conducted first-ever graph theoretical network analyses in fXPCs using thirty-direction diffusion-weighted MRI acquired from 42 healthy controls aged 18–44 years (HC; 22 male and 20 female) and 46 fXPCs (16 male and 30 female). Globally, we found no differences between the fXPCs and HCs within each gender for all global graph theoretical measures. In male fXPCs, global efficiency was significantly negatively associated with the number of CGG repeats. For nodal measures, significant group differences were found between male fXPCs and male HCs in the right fusiform and the right ventral diencephalon (for nodal efficiency), and in the left hippocampus (for nodal clustering coefficient). In female fXPCs, clustering coefficient in the left superior parietal cortex correlated with counting performance in an enumeration task.
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DOI：
10.1007/978-3-642-33418-4_25
发表时间：
2012
期刊：
LECTURE NOTES IN ARTIFICIAL INTELLIGENCE
影响因子：
--
作者：
GadElkarim, Johnson J.;Schonfeld, Dan;Ajilore, Olusola;Zhan, Liang;Zhang, Aifeng F.;Feusner, Jamie D.;Thompson, Paul M.;Simon, Tony J.;Kumar, Anand;Leow, Alex D.
通讯作者：
Leow, Alex D.
影响因子：
2.9
作者：
Goodrich-Hunsaker, Naomi J;Wong, Ling M;Simon, Tony J
通讯作者：
Simon, Tony J
DOI：
10.4088/jcp.08m04476
发表时间：
2009-06
期刊：
The Journal of clinical psychiatry
影响因子：
--
作者：
Bourgeois JA;Coffey SM;Rivera SM;Hessl D;Gane LW;Tassone F;Greco C;Finucane B;Nelson L;Berry-Kravis E;Grigsby J;Hagerman PJ;Hagerman RJ
通讯作者：
Hagerman RJ
影响因子：
8.6
作者：
Hashimoto, Ryu-ichiro;Srivastava, Siddharth;Rivera, Susan M.
通讯作者：
Rivera, Susan M.
影响因子：
7.2
作者：
Ajilore, Olusola;Lamar, Melissa;Kumar, Anand
通讯作者：
Kumar, Anand