Evaluation of the impact of gastric bypass surgery on eating behaviour using objective methodologies under residential conditions: Rationale and study protocol.
Evaluation of the impact of gastric bypass surgery on eating behaviour using objective methodologies under residential conditions: Rationale and study protocol.
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DOI：
10.1016/j.conctc.2021.100846
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发表时间：
2021-12
影响因子：
1.5
通讯作者：
Livingstone MBE
中科院分区：
文献类型：
--
作者：
Redpath T;Naseer F;Price RK;Boyd A;Martin M;le Roux CW;Spector AC;Livingstone MBE
胃旁路手术可以显著和持续地减轻体重，并降低严重肥胖患者的相关健康风险。虽然减少能量摄入（EI）是手术后体重减轻的主要驱动因素，但这种能量不足的潜在机制尚不清楚。由于在评估食物摄入量时缺乏符合目的的方法，加上随访研究相对较短，证据基础受到限制。本文描述了一项观察性、全住宅研究的基本原理和方案，该研究使用隐蔽、客观的方法来评估术前1个月、术后3个月、12个月和24个月患者（n = 31）与体重稳定对照组（n = 32）相比，24小时食物摄入量的变化。主要研究终点包括情商、常量营养素摄入量、食物偏好和进食行为（进食速度、频率和持续时间）的变化。其他可能影响EI和体重调节的生理变化，包括身体组成、循环食欲激素、静息代谢率、总能量消耗和胃肠道症状的变化也被评估。了解哪些机制有助于降低EI和术后体重减轻，可能有助于确定哪些人最有可能从胃绕道手术中受益，以及哪些人可能需要更有针对性的干预来优化术后体重减轻。此外，这些机制的澄清也可能为肥胖的非手术治疗提供有针对性的方法。
Gastric bypass surgery leads to significant and sustained weight loss and a reduction in associated health risks in individuals with severe obesity. While reduced energy intake (EI) is the primary driver of weight loss following surgery, the underlying mechanisms accounting for this energy deficit are not well understood. The evidence base has been constrained by a lack of fit-for-purpose methodology in assessing food intake coupled with follow-up studies that are relatively short-term. This paper describes the underlying rationale and protocol for an observational, fully residential study using covert, objective methodology to evaluate changes in 24-hr food intake in patients (n = 31) at 1-month pre-surgery and 3-, 12- and 24-months post-surgery, compared to weight-stable controls (n = 32). The main study endpoints included change in EI, macronutrient intake, food preferences, and eating behaviours (speed, frequency, and duration of eating). Other physiological changes that may influence EI and weight regulation including changes in body composition, circulating appetite hormones, resting metabolic rate, total energy expenditure and gastrointestinal symptoms were also evaluated. Understanding which mechanisms contribute to a reduction in EI and weight loss post-surgery could potentially help to identify those individuals who are most likely to benefit from gastric bypass surgery as well as those that may need more targeted intervention to optimise their weight loss post-surgery. Furthermore, clarification of these mechanisms may also inform targeted approaches for non-surgical treatments of obesity.
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影响因子：
9
作者：
BROLIN, RE;ROBERTSON, LB;CODY, RP
通讯作者：
CODY, RP
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