Neurobehavioral Effects of LSVT(®) LOUD on Auditory-Vocal Integration in Parkinson's Disease: A Preliminary Study.
Neurobehavioral Effects of LSVT(®) LOUD on Auditory-Vocal Integration in Parkinson's Disease: A Preliminary Study.
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LSVT（®）LOUD对帕金森病听-声整合神经行为影响的初步研究
DOI：
10.3389/fnins.2021.624801
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发表时间：
2021
影响因子：
4.3
通讯作者：
Liu H
中科院分区：
文献类型：
--
作者：
Li Y;Tan M;Fan H;Wang EQ;Chen L;Li J;Chen X;Liu H
帕金森氏病（PD）患者的发音-发声整合功能受损，其特征是在发声的自我监测过程中对听觉反馈错误的异常代偿反应。本研究探讨了听觉反馈控制的音高生产在PD是否可以受益于李西尔弗曼语音治疗（LSVT® LOUD），高努力，密集的语音治疗运动功能减退性构音障碍的PD。在LSVT LOUD之前和之后，12名PD患者被指示发出持续的元音，同时听到他们的声音意外地音高移动了-200美分。测量他们对音高扰动的发声反应和事件相关电位（ERP），以评估治疗效果。一组12名健康对照者按年龄、性别和语言进行一对一配对。PD患者表现出异常增强的声音和ERP P2反应，音高扰动相对于健康对照组。然而，LSVT LOUD的成功治疗导致了明显更小和更快的声音补偿，伴随着明显更大的P2反应。此外，在段落阅读过程中提高的声音响度与音调扰动的声音补偿减少显著相关。这些初步研究结果提供了LSVT LOUD对PD相关的受损发音-发声整合的有益作用的第一个神经行为证据，这可能与LSVT LOUD改善喉运动功能和自上而下的言语运动网络调制有关。
Individuals with Parkinson’s disease (PD) are impaired in auditory-vocal integration, characterized by abnormal compensatory responses to auditory feedback errors during self-monitoring of vocal production. The present study examined whether auditory feedback control of vocal pitch production in PD can benefit from Lee Silverman voice treatment (LSVT® LOUD), a high effort, intensive speech treatment for hypokinetic dysarthria in PD. Before and immediately after LSVT LOUD, 12 individuals with PD were instructed to produce sustained vowel sounds while hearing their voice unexpectedly pitch-shifted by −200 cents. Their vocal responses and event-related potentials (ERPs) to pitch perturbations were measured to assess the treatment outcomes. A group of 12 healthy controls were one-to-one pair matched by age, sex, and language. Individuals with PD exhibited abnormally enhanced vocal and ERP P2 responses to pitch perturbations relative to healthy controls. Successful treatment with LSVT LOUD, however, led to significantly smaller and faster vocal compensations that were accompanied by significantly larger P2 responses. Moreover, improved vocal loudness during passage reading was significantly correlated with reduced vocal compensations for pitch perturbations. These preliminary findings provide the first neurobehavioral evidence for beneficial effects of LSVT LOUD on impaired auditory-vocal integration associated with PD, which may be related to improved laryngeal motor functions and a top-down modulation of the speech motor network by LSVT LOUD.
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影响因子：
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作者：
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DOI：
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发表时间：
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期刊：
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影响因子：
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通讯作者：
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