Early sensory processing deficits predict sensitivity to distraction in schizophrenia.
Early sensory processing deficits predict sensitivity to distraction in schizophrenia.
复制标题
DOI：
10.1016/j.schres.2013.03.025
复制
发表时间：
2013-06
影响因子：
4.5
通讯作者：
Tregellas JR
中科院分区：
文献类型：
--
作者：
Smucny J;Olincy A;Eichman LC;Lyons E;Tregellas JR
Patients with schizophrenia frequently report difficulties paying attention during important tasks, because they are distracted by noise in the environment. The neurobiological mechanism underlying this problem is, however, poorly understood. The goal of this study was to determine if early sensory processing deficits contribute to sensitivity to distracting noise in schizophrenia. To that end, we examined the effect of environmentally relevant distracting noise on performance of an attention task in 19 patients with schizophrenia and 22 age and gender-matched healthy comparison subjects. Using electroencephalography, P50 auditory gating ratios also were measured in the same subjects and were examined for their relationship to noise-induced changes in performance on the attention task. Positive symptoms also were evaluated in patients. Distracting noise caused a greater increase in reaction time in patients, relative to comparison subjects, on the attention task. Higher P50 auditory gating ratios also were observed in patients. P50 gating ratio significantly correlated with the magnitude of noise-induced increase in reaction time. Noise-induced increase in reaction time was associated with delusional thoughts in patients. P50 ratios were associated with delusional thoughts and hallucinations in patients. In conclusion, the observation of noise effects on attention in patients is consistent with subjective reports from patients. The observed relationship between noise effects on reaction time and P50 auditory gating support the hypothesis that early inhibitory processing deficits may contribute to susceptibility to distraction in the illness.
登录
查看更多内容
影响因子：
10.6
作者：
ADLER, LE;HOFFER, LJ;FREEDMAN, R
通讯作者：
FREEDMAN, R
影响因子：
10.5
作者：
LAWSON, JS;MCGHIE, A;CHAPMAN, J
通讯作者：
CHAPMAN, J
影响因子：
10.6
作者：
Jin, Y;Bunney, WE;Potkin, SG
通讯作者：
Potkin, SG
影响因子：
4.5
作者：
O'Grada, Cara;Barry, Sandra;Donohoe, Gary
通讯作者：
Donohoe, Gary
影响因子：
17.7
作者：
Adler, LE;Olincy, A;Freedman, R
通讯作者：
Freedman, R