Future novel therapeutic agents for Clostridium difficile infection.
Future novel therapeutic agents for Clostridium difficile infection.
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DOI：
10.1517/13543784.2010.495386
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发表时间：
2010-07
影响因子：
6.1
通讯作者：
Dupont HL
中科院分区：
文献类型：
--
作者：
Koo HL;Garey KW;Dupont HL
艰难梭菌是医疗获得性腹泻的最重要的可确定原因。与这种肠道病原体相关的发病率和死亡率的增加以及当前抗生素治疗失败和复发的显著率强调了发现新的和改进的治疗和预防剂的需要。我们回顾了即将出现的新型治疗药物和临床证据，以支持其治疗C。艰难感染我们还提供了一个广泛的比较抗菌药物的敏感性C。基于文献中发表的体外亲和性，这项审查是通过彻底检查公共来源，包括期刊和科学会议摘要，截至2009年2月。许多新的治疗药物正在开发中，并正在临床试验中进行测试。然而，高成本和对耐药性的担忧可能会限制这些抗菌剂用于治疗C。艰难感染被动和主动免疫治疗可能具有重要的未来作用，作为治疗和预防C。艰难感染
Clostridium difficile is the most important definable cause of healthcare acquired diarrhea. The increasing incidence and mortality associated with this enteric pathogen and the significant rate of treatment failures and recurrences with current antibiotics emphasize the need for discovery of new and improved therapeutic and preventative agents. We review upcoming novel therapeutic agents and the clinical evidence to support their efficacy in treating C. difficile infection. We also provide an extensive comparison of antimicrobial susceptibilities of C. difficile based on in vitro susceptibilities published in the literature. This review was conducted by thorough examination of the public sources, including journals and scientific meeting abstracts, up to February 2009. A number of new therapeutic agents are in development and being tested in clinical trials. However, high costs and concerns for resistance may limit the use of these antimicrobials for the treatment of C. difficile infection. Passive and active immunotherapy may have important future roles as therapeutic and preventative strategies for C. difficile infection.
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影响因子：
11.8
作者：
Curry, Scott R.;Marsh, Jane W.;Harrison, Lee H.
通讯作者：
Harrison, Lee H.
影响因子：
2.3
作者：
Citron, D. M.;Babakhani, F.;Gerding, D. N.
通讯作者：
Gerding, D. N.
影响因子：
4.9
作者：
Citron, DM;Merriam, CV;Goldstein, EJC
通讯作者：
Goldstein, EJC
影响因子：
24.5
作者：
BOLTON, RP;CULSHAW, MA
通讯作者：
CULSHAW, MA
DOI：
10.1007/bf01691117
发表时间：
1998-03-01
影响因子：
4.5
作者：
Edlund, C;Sabouri, S;Nord, CE
通讯作者：
Nord, CE