Cancer therapy's impact on lipid metabolism: Mechanisms and future avenues.
Cancer therapy's impact on lipid metabolism: Mechanisms and future avenues.
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DOI：
10.3389/fcvm.2022.925816
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发表时间：
2022
影响因子：
3.6
通讯作者：
Sallam T
中科院分区：
文献类型：
--
作者：
Bhatnagar R;Dixit NM;Yang EH;Sallam T
动脉粥样硬化性心血管疾病是癌症患者中日益严重的威胁。毫不奇怪，癌症靶向治疗与代谢失调有关，包括局部和全身脂质代谢的变化。因此，肿瘤发展和癌症治疗与胆固醇代谢密切相关，可能是该人群心血管发病率和死亡率增加的驱动因素。化疗药物通过多种机制影响脂质代谢。在这篇综述中，我们强调了常用的细胞毒性治疗与胆固醇代谢和潜在的机会，以限制动脉粥样硬化的风险，在这一患者群体的机制和临床证据。更好地了解动脉粥样硬化，癌症治疗和胆固醇代谢之间的联系可能会为癌症患者提供最佳脂质治疗并减轻心血管疾病负担。
Atherosclerotic cardiovascular disease is a growing threat among cancer patients. Not surprisingly, cancer-targeting therapies have been linked to metabolic dysregulation including changes in local and systemic lipid metabolism. Thus, tumor development and cancer therapeutics are intimately linked to cholesterol metabolism and may be a driver of increased cardiovascular morbidity and mortality in this population. Chemotherapeutic agents affect lipid metabolism through diverse mechanisms. In this review, we highlight the mechanistic and clinical evidence linking commonly used cytotoxic therapies with cholesterol metabolism and potential opportunities to limit atherosclerotic risk in this patient population. Better understanding of the link between atherosclerosis, cancer therapy, and cholesterol metabolism may inform optimal lipid therapy for cancer patients and mitigate cardiovascular disease burden.
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影响因子：
11.1
作者：
Calvillo-Arguelles, Oscar;Schoffel, Alice;Capo-Chichi, Jose-Mario;Abdel-Qadir, Husam;Schuh, Andre;Carrillo-Estrada, Montserrat;Liu, Shiying;Gupta, Vikas;Schimmer, Aaron D.;Yee, Karen;Shlush, Liran, I;Natarajan, Pradeep;Thavendiranathan, Paaladinesh
通讯作者：
Thavendiranathan, Paaladinesh
影响因子：
--
作者：
BELL, RA;WAGGONER, PM;YEE, CE
通讯作者：
YEE, CE
影响因子：
3.8
作者：
Arpino, Grazia;De Angelis, Carmine;De Placido, Sabino
通讯作者：
De Placido, Sabino
DOI：
10.1249/mss.0b013e31816c091d
发表时间：
2008-07-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Butcher, Lee R.;Thomas, Andrew;Morris, Keith
通讯作者：
Morris, Keith
影响因子：
1.9
作者：
Arem, Hannah;Loftfield, Erikka
通讯作者：
Loftfield, Erikka