Genome-wide association analysis of thirty one production, health, reproduction and body conformation traits in contemporary U.S. Holstein cows.
Genome-wide association analysis of thirty one production, health, reproduction and body conformation traits in contemporary U.S. Holstein cows.
复制标题
DOI：
10.1186/1471-2164-12-408
复制
发表时间：
2011-08-11
期刊：
影响因子：
4.4
通讯作者：
Da Y
中科院分区：
文献类型：
--
作者：
Cole JB;Wiggans GR;Ma L;Sonstegard TS;Lawlor TJ Jr;Crooker BA;Van Tassell CP;Yang J;Wang S;Matukumalli LK;Da Y
全基因组关联分析是一个强大的工具，用于注释基因组上的表型效应和与奶牛表型相关的基因和染色体区域的知识是有用的基因组和基因为基础的选择。在这里，我们报告的结果，全基因组分析预测的传播能力（PTA）的31个生产，健康，繁殖和身体形态性状在当代荷斯坦奶牛。全基因组关联分析确定了一些候选基因和染色体区域与当代美国荷斯坦奶牛的31个乳制品性状。高度显著的基因和染色体区域包括：BTA 13的GNAS区域用于产奶、脂肪和蛋白质产量; BTA 7的INSR区域和BTAX的LOC 520057和GRIA 3用于女儿怀孕率、体细胞评分和生产寿命; BTA 2的LRP 1B用于体细胞评分; BTA 14的DGAT 1-NIBP区域用于脂肪百分比; BTA 1的FKBP 2用于蛋白质产量和百分比，BTA 26的MGMT和BTA 6的PDGFRA用于蛋白质百分比，BTA 18的53.9-58.7 Mb区域用于服务公畜和女儿产犊容易性和服务公畜死胎，BTA 18的PGLYRP 1-IGFL 1区域用于大量性状; BTA 18的L0 C787057用于服务公畜死胎和女儿产犊容易度; BTA 15的CD 82、BTA 23的DST和MOCS 1-LRFN 2区域用于女儿死胎;以及BTAX的L0 C520057和GRIA 3用于女儿妊娠率。体型性状中，BTA 11、BTAX、BTA 10、BTA 5和BTA 26的SNP效应浓度最大，而体型性状中BTAX的PHKA 2和BTA 16的REN效应浓度最大。体型性状中，BTAX、BTA 19和BTA 3达到显著水平。乳房性状受BTA 16、BTA 22、BTAX、BTA 2、BTA 10、BTA 11、BTA 20、BTA 22和BTA 25的影响，乳头性状受BTA 6、BTA 7、BTA 9、BTA 16、BTA 11、BTA 26和BTA 17的影响，足/腿性状受BTA 11、BTA 13、BTA 18、BTA 20和BTA 26的影响。全基因组关联分析确定了一些基因和染色体区域与当代荷斯坦奶牛的31个生产，健康，繁殖和身体形态性状。这些结果为奶牛基因组表型效应的注释和奶牛QTL效应的一致性研究提供了有用的信息。
Genome-wide association analysis is a powerful tool for annotating phenotypic effects on the genome and knowledge of genes and chromosomal regions associated with dairy phenotypes is useful for genome and gene-based selection. Here, we report results of a genome-wide analysis of predicted transmitting ability (PTA) of 31 production, health, reproduction and body conformation traits in contemporary Holstein cows. Genome-wide association analysis identified a number of candidate genes and chromosome regions associated with 31 dairy traits in contemporary U.S. Holstein cows. Highly significant genes and chromosome regions include: BTA13's GNAS region for milk, fat and protein yields; BTA7's INSR region and BTAX's LOC520057 and GRIA3 for daughter pregnancy rate, somatic cell score and productive life; BTA2's LRP1B for somatic cell score; BTA14's DGAT1-NIBP region for fat percentage; BTA1's FKBP2 for protein yields and percentage, BTA26's MGMT and BTA6's PDGFRA for protein percentage; BTA18's 53.9-58.7 Mb region for service-sire and daughter calving ease and service-sire stillbirth; BTA18's PGLYRP1-IGFL1 region for a large number of traits; BTA18's LOC787057 for service-sire stillbirth and daughter calving ease; BTA15's CD82, BTA23's DST and the MOCS1-LRFN2 region for daughter stillbirth; and BTAX's LOC520057 and GRIA3 for daughter pregnancy rate. For body conformation traits, BTA11, BTAX, BTA10, BTA5, and BTA26 had the largest concentrations of SNP effects, and PHKA2 of BTAX and REN of BTA16 had the most significant effects for body size traits. For body shape traits, BTAX, BTA19 and BTA3 were most significant. Udder traits were affected by BTA16, BTA22, BTAX, BTA2, BTA10, BTA11, BTA20, BTA22 and BTA25, teat traits were affected by BTA6, BTA7, BTA9, BTA16, BTA11, BTA26 and BTA17, and feet/legs traits were affected by BTA11, BTA13, BTA18, BTA20, and BTA26. Genome-wide association analysis identified a number of genes and chromosome regions associated with 31 production, health, reproduction and body conformation traits in contemporary Holstein cows. The results provide useful information for annotating phenotypic effects on the dairy genome and for building consensus of dairy QTL effects.
登录
查看更多内容
影响因子：
5.3
作者：
Leimkühler, S;Charcosset, M;Reiss, J
通讯作者：
Reiss, J
DOI：
10.1073/pnas.0308518100
发表时间：
2004-02-24
影响因子：
11.1
作者：
Grisart, B;Farnir, F;Georges, M
通讯作者：
Georges, M
影响因子：
3
作者：
Ma, Li;Runesha, H. Birali;Dvorkin, Daniel;Garbe, John R.;Da, Yang
通讯作者：
Da, Yang
影响因子：
3.3
作者：
Mai, M. D.;Sahana, G.;Guldbrandtsen, B.
通讯作者：
Guldbrandtsen, B.
影响因子：
3.7
作者：
Matukumalli LK;Lawley CT;Schnabel RD;Taylor JF;Allan MF;Heaton MP;O'Connell J;Moore SS;Smith TP;Sonstegard TS;Van Tassell CP
通讯作者：
Van Tassell CP