Geographical Distribution of Genetic Variants and Lineages of SARS-CoV-2 in Chile.

Geographical Distribution of Genetic Variants and Lineages of SARS-CoV-2 in Chile.
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DOI:
10.3389/fpubh.2020.562615
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发表时间:
2020
影响因子:
5.2
通讯作者:
Fernández J
Fernández J
中科院分区:
医学3区
文献类型:
--
作者:
Castillo AE;Parra B;Tapia P;Lagos J;Arata L;Acevedo A;Andrade W;Leal G;Tambley C;Bustos P;Fasce R;Fernández J

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由新型严重急性呼吸综合征冠状病毒2(SARS-CoV-2)引起的大流行是一个世界性的公共卫生问题。SARS-CoV-2最初局限于中国,然后在欧洲和美洲广泛传播,它影响和推动了世界各地的科学界,以一种快速和协调的方式工作,收集有关这种病毒的所有可能信息,并制定新的战略和方案,试图阻止感染。在2020年3月期间,在公共数据库中共享了16000多个完整的病毒基因组,这些数据库允许构建基因图谱,用于跟踪和监测病毒随时间的进展,并研究地理区域存在的基因组变异。在这项工作中,我们介绍了2020年3月至4月期间在智利发生的SARS-CoV-2基因变异和谱系。对来自智利不同地区的141份病毒样本进行的完整基因组分析显示,与欧洲和美国一样,D614G变异占主导地位,并主要存在B.1系。这些发现可能有助于采取控制措施,因为智利现有的病毒变种与其他国家相似,并监测该国病毒变种的动态变化。
The pandemic caused by the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a worldwide public health concern. First confined in China and then disseminated widely across Europe and America, SARS-CoV-2 has impacted and moved the scientific community around the world to working in a fast and coordinated way to collect all possible information about this virus and generate new strategies and protocols to try to stop the infection. During March 2020, more than 16,000 full viral genomes have been shared in public databases that allow the construction of genetic landscapes for tracking and monitoring the viral advances over time and study the genomic variations present in geographic regions. In this work, we present the occurrence of genetic variants and lineages of SARS-CoV-2 in Chile during March to April 2020. Complete genome analysis of 141 viral samples from different regions of Chile revealed a predominance of variant D614G like in Europe and the USA and the major presence of lineage B.1. These findings could help take control measures due to the similarity of the viral variants present in Chile, compared with other countries, and monitor the dynamic change of virus variants in the country.
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