A terrifying sound stress inhibits hippocampal neurogenesis in the adult male mice
A terrifying sound stress inhibits hippocampal neurogenesis in the adult male mice
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可怕的声音压力抑制成年雄性小鼠的海马神经发生
DOI：
10.1002/jdn.10160
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发表时间：
2021-11
影响因子：
1.8
通讯作者：
Huang Chen
中科院分区：
文献类型：
--
作者：
Li Zhaoxin;Zhao Zixuan;Nan Zhuhui;Duan Jingwen;Zhang Siyuan;Zhang Zhichao;Huang Chen
Stress impairs hippocampal neurogenesis. The traditional animal model of stress contains a mixture of physical and psychological stress factors. This leads to difficulty in the evaluation of the effect of pure psychological stress on neurogenesis. In this study, we investigated the effect of pure psychological stress on hippocampal neurogenesis. The pure psychological stress model and the mixed stress model were carried out by terrifying sound and restraint, respectively. The open field test showed that restraint treatment improved the general locomotor activity levels, while terrifying sound treatment had opposite effects. Compared with a normal condition, both terrifying sound stimulation and restraint treatment significantly decreased the number of BrdU and Ki‐67 and reduced the positive rate of SOX2/GFAP in the hippocampus. These phenomena indicated that pure psychological stress could decrease the number of neural stem cells and inhibit cell proliferation in the hippocampus of a mouse. Furthermore, compared with the restraint treatment, the neurotransmitters including norepinephrine (NE), 5‐hydroxytryptamine (5‐HT), and gamma‐aminobutyric acid (GABA) had not been affected drastically by terrifying sound stimulation. Our results suggest that the terrifying sound stimulation can be considered as a novel and effective pure psychological stress animal model for the further research on the hippocampus.
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影响因子：
2.5
作者：
Shan T;Ma J;Ma Q;Guo K;Guo J;Li X;Li W;Liu J;Huang C;Wang F;Wu E
通讯作者：
Wu E
影响因子：
4.3
作者：
Pineda JR;Encinas JM
通讯作者：
Encinas JM
影响因子：
3.6
作者：
Catavero C;Bao H;Song J
通讯作者：
Song J
恐怖声音应激诱导成年雄性大鼠海马蛋白质组变化
DOI：
10.1016/j.physbeh.2014.01.038
发表时间：
2014-04
期刊：
Physiology & Behavior
影响因子：
--
作者：
Lingyu Zhao;Xiaoge Zhao;Tusheng Song;Chen Huang
通讯作者：
Chen Huang
组蛋白甲基化定义小鼠脑室下区的神经干/祖细胞亚型
影响因子：
5.1
作者：
Zhang Zhichao;Manaf Adeel;Li Yanjiao;Perez Sonia Pena;Suganthan Rajikala;Dahl John Arne;Bjoras Magnar;Klungl;Arne
通讯作者：
Arne