Correlation of Arthroscopic Grading and Optical Coherence Tomography as Markers of Early Repair and Predictors of Later Healing Evident on MRI and Histomorphometric Assessment of Cartilage Defects Implanted with Chondrocytes Overexpressing IGF-I.
Correlation of Arthroscopic Grading and Optical Coherence Tomography as Markers of Early Repair and Predictors of Later Healing Evident on MRI and Histomorphometric Assessment of Cartilage Defects Implanted with Chondrocytes Overexpressing IGF-I.
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DOI：
10.1177/19476035231154508
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发表时间：
2023-06
期刊：
影响因子：
2.8
通讯作者：
Ortved, Kyla F.
中科院分区：
文献类型：
--
作者：
Ciamillo, Sarah A.;Pownder, Sarah L.;Potter, Hollis G.;Stefanovski, Darko;Nixon, Alan J.;Ortved, Kyla F.
关键词：
Injury of articular cartilage is common, and due to the poor intrinsic capabilities of chondrocytes, it can precipitate joint degradation and osteoarthritis (OA). Implantation of autologous chondrocytes into cartilaginous defects has been used to bolster repair. Accurate assessment of the quality of repair tissue remains challenging. This study aimed to investigate the utility of noninvasive imaging modalities, including arthroscopic grading and optical coherence tomography (OCT) for assessment of early cartilage repair (8 weeks), and MRI to determine long-term healing (8 months). Large (15 mm diameter), full-thickness chondral defects were created on both lateral trochlear ridges of the femur in 24 horses. Defects were implanted with autologous chondrocytes transduced with rAAV5-IGF-I, autologous chondrocytes transduced with rAAV5-GFP, naïve autologous chondrocytes, or autologous fibrin. Healing was evaluated at 8 weeks post-implantation using arthroscopy and OCT, and at 8 months post-implantation using MRI, gross pathology, and histopathology. OCT and arthroscopic scoring of short-term repair tissue were significantly correlated. Arthroscopy was also correlated with later gross pathology and histopathology of repair tissue at 8 months post-implantation, while OCT was not correlated. MRI was not correlated with any other assessment variable. This study indicated that arthroscopic inspection and manual probing to develop an early repair score may be a better predictor of long-term cartilage repair quality following autologous chondrocyte implantation. Furthermore, qualitative MRI may not provide additional discriminatory information when assessing mature repair tissue, at least in this equine model of cartilage repair.
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影响因子：
2.8
作者：
Fortier, LA;Lust, G;Nixon, AJ
通讯作者：
Nixon, AJ
影响因子：
2.6
作者：
Murata D;Ishikawa S;Sunaga T;Saito Y;Sogawa T;Nakayama K;Hobo S;Hatazoe T
通讯作者：
Hatazoe T
DOI：
10.1002/jor.20998
发表时间：
2010-04
期刊：
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
影响因子：
--
作者：
Bear DM;Williams A;Chu CT;Coyle CH;Chu CR
通讯作者：
Chu CR
影响因子：
3.5
作者：
Chu, Constance R.;Izzo, Nicholas J.;Studer, Rebecca K.
通讯作者：
Studer, Rebecca K.
影响因子：
2.3
作者：
Bear DM;Szczodry M;Kramer S;Coyle CH;Smolinski P;Chu CR
通讯作者：
Chu CR