Optical coherence tomography grading correlates with MRI T2 mapping and extracellular matrix content.
Optical coherence tomography grading correlates with MRI T2 mapping and extracellular matrix content.
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DOI：
10.1002/jor.20998
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发表时间：
2010-04
期刊：
影响因子：
--
通讯作者：
Chu CR
中科院分区：
文献类型：
--
作者：
Bear DM;Williams A;Chu CT;Coyle CH;Chu CR
光学相干断层扫描(OCT)和T2映射是新兴的临床成像技术，有可能检测到软骨表面下的变化，保持宏观上完整的关节表面。这项研究验证了OCT与磁共振成像(MRI)T2值相关，以及OCT信号对软骨基质退变敏感的假设。经MRI T2标测，取自5个人胫骨平台的骨软骨核45个。行OCT成像，按以下分级：A，明显的双折射；B，无双折射；C，表面下空洞和/或不规则表面。测定细胞外基质含量，并对核心进行组织学和偏光显微镜(PLM)评估。B级和C级岩心的表层T2值比A级岩心高25%(p=0.047)，深层T2值高50%(p=0.012)。B级和C级核的糖胺聚糖(GAG)含量比A级核高36%(p=0.009)。组织学和PLM显示，随着OCT分级的增加，表面不规则性和结构紊乱增加。OCT分级和T2值随着胶原结构紊乱程度的增加而增加，提示MRI T2标测和OCT对胶原结构的改变较为敏感。我们的结果证明OCT和T2标测图能够发现临床正常的软骨的早期退变。
Optical coherence tomography (OCT) and T2 mapping are emerging clinical imaging technologies with potential to detect subsurface changes in cartilage retaining a macroscopically intact articular surface. This study tests the hypothesis that OCT correlates with magnetic resonance imaging (MRI) T2 values, and that OCT signal is sensitive to cartilage matrix degeneration. Forty-five osteochondral cores were harvested from five human tibial plateau explants after MRI T2 mapping. Cores underwent OCT imaging and were graded as follows: A, obvious birefringence; B, no birefringence; C, subsurface voids and/or irregular surface. Extracellular matrix content was determined and cores underwent histologic and polarized light microscopy (PLM) evaluation. Grade B and C cores had 25% higher superficial T2 values (p = 0.047) and 50% higher deep T2 values (p = 0.012) than grade A cores. Grade B and C cores had 36% higher glycosaminoglycan (GAG) content compared to grade A cores (p = 0.009). Histology and PLM demonstrated increased surface irregularity and structural disorganization with increasing OCT grade. OCT grade and T2 value increased with increasing collagen disorganization, suggesting that MRI T2 mapping and OCT are sensitive to changes in collagen structure. Our results demonstrate the ability of OCT and T2 mapping to detect early cartilage degeneration in clinically normal appearing cartilage.
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影响因子：
--
作者：
Hootman, JM;Helmick, CG
通讯作者：
Helmick, CG
影响因子：
19.7
作者：
Mosher, TJ;Dardzinski, BJ;Smith, MB
通讯作者：
Smith, MB
影响因子：
3.5
作者：
Chu, Constance R.;Izzo, Nicholas J.;Studer, Rebecca K.
通讯作者：
Studer, Rebecca K.
DOI：
10.1016/s0005-8165(73)80016-2
发表时间：
1973-01-01
期刊：
BEITRAGE ZUR PATHOLOGIE
影响因子：
--
作者：
PUCHTLER, H;WALDROP, FS;VALENTINE, LS
通讯作者：
VALENTINE, LS
影响因子：
15.9
作者：
LIPPIELLO, L;HALL, D;MANKIN, HJ
通讯作者：
MANKIN, HJ