How B cells influence bone biology in health and disease.
How B cells influence bone biology in health and disease.
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DOI：
10.1016/j.bone.2010.06.011
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发表时间：
2010-09
期刊：
影响因子：
4.1
通讯作者：
Lorenzo, Joseph A.
中科院分区：
文献类型：
--
作者：
Horowitz, Mark C.;Fretz, Jackie A.;Lorenzo, Joseph A.
关键词：
现在已经确定，造血、免疫和骨骼系统中的细胞之间发生重要的调节相互作用（骨免疫学）。B淋巴细胞（B细胞）负责体内抗体或免疫球蛋白的产生和生产。这些淋巴细胞与T细胞一起构成了适应性免疫系统，该系统使个体能够对感染产生特异性反应并保留对该感染的记忆，从而在再次发生相同感染时能够做出更快、更强有力的反应。除了这种免疫功能外，B细胞与骨细胞有着密切而多方面的关系。B细胞在骨内膜骨表面发现的支持性小生境中从造血干细胞（HSC）分化。成骨细胞谱系中的细胞支持HSC和B细胞在这些小生境中分化。B细胞分化至少部分地受一系列以时间方式起作用的转录因子调节。虽然这些转录因子是B细胞分化所必需的，但它们的缺失导致骨表型的深刻变化。这部分是由于巨噬细胞/破骨细胞和B细胞分化之间的密切关系。B细胞和骨细胞之间的相互作用与RANKL-RANK、OPG信号传导轴的缺陷相互作用，导致骨表型改变。虽然B细胞在正常骨重建过程中的作用似乎很小，但活化的B细胞在许多伴有骨变化的炎性疾病中起重要作用。本文综述了B细胞和骨细胞之间的关系，以及这种关系如何影响健康和疾病期间的骨骼和造血。
It is now well established that important regulatory interactions occur between the cells in the hematopoietic, immune and skeletal systems (osteoimmunology). B lymphocytes (B cells) are responsible for the generation and production of antibodies or immunoglobulins in the body. Together with T cells these lymphocytes comprise the adaptive immune system, which allows an individual to develop specific responses to an infection and retain memory of that infection, allowing for a faster and more robust response if that same infection occurs again. In addition to this immune function, B cells have a close and multifaceted relationship with bone cells. B cells differentiate from hematopoietic stem cells (HSCs) in supportive niches found on endosteal bone surfaces. Cells in the osteoblast lineage support HSC and B cell differentiation in these niches. B cell differentiation is regulated, at least in part, by a series of transcription factors that function in a temporal manner. While these transcription factors are required for B cell differentiation, their loss causes profound changes in the bone phenotype. This is due, in part, to the close relationship between macrophage/osteoclast and B cell differentiation. Cross talk between B cells and bone cells is reciprocal with defects in the RANKL-RANK, OPG signaling axis resulting in altered bone phenotypes. While the role of B cells during normal bone remodeling appears minimal, activated B cells play an important role in many inflammatory diseases with associated bony changes. This review examines the relationship between B cells and bone cells and how that relationship affects the skeleton and hematopoiesis during health and disease.
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影响因子：
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作者：
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