Nonalcoholic fatty liver disease - A multisystem disease?
Nonalcoholic fatty liver disease - A multisystem disease?
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DOI：
10.3748/wjg.v22.i43.9488
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发表时间：
2016-11-21
影响因子：
4.3
通讯作者：
Orlic L
中科院分区：
文献类型：
--
作者：
Mikolasevic I;Milic S;Turk Wensveen T;Grgic I;Jakopcic I;Stimac D;Wensveen F;Orlic L
非酒精性脂肪性肝病(NAFLD)是与超重和代谢综合征(METS)相关的最常见的并发症之一。重要的是，NAFLD是其最危险的并发症之一，因为它会导致严重的肝脏病理，包括纤维化、肝硬变和肝细胞癌。鉴于肥胖在全球范围内的日益流行，NAFLD已成为慢性肝病的最常见原因，因此是一个重大的全球健康问题。目前，NAFLD主要被认为是METS的肝脏表现。然而，越来越多的证据表明，NAFLD的影响范围超出肝脏，与一系列慢性疾病呈负相关，最明显的是心血管疾病(CVD)、2型糖尿病(T2 DM)和慢性肾脏疾病(CKD)。越来越清楚的是，这些疾病是与甲硫氨酸相关的相同潜在病理生理过程的结果，如胰岛素抵抗、慢性全身炎症和血脂异常。因此，它们已被证明是相互独立的风险因素。此外，最近的数据表明，NAFLD积极促进了CVD、T2 DM和CKD以及其他几种病理的病理生理学恶化。因此，NAFLD是许多与蛋氨酸相关的慢性疾病的直接原因，因此迫切需要更好地检测和治疗脂肪肝疾病。随着肝病的非侵入性筛查方法日益普及，甲亢症患者中NAFLD的检测和治疗应被(次级)专科医生和初级保健医生考虑。
Non-alcoholic fatty liver disease (NAFLD) is one of the most common comorbidities associated with overweight and metabolic syndrome (MetS). Importantly, NAFLD is one of its most dangerous complications because it can lead to severe liver pathologies, including fibrosis, cirrhosis and hepatic cellular carcinoma. Given the increasing worldwide prevalence of obesity, NAFLD has become the most common cause of chronic liver disease and therefore is a major global health problem. Currently, NAFLD is predominantly regarded as a hepatic manifestation of MetS. However, accumulating evidence indicates that the effects of NAFLD extend beyond the liver and are negatively associated with a range of chronic diseases, most notably cardiovascular disease (CVD), diabetes mellitus type 2 (T2DM) and chronic kidney disease (CKD). It is becoming increasingly clear that these diseases are the result of the same underlying pathophysiological processes associated with MetS, such as insulin resistance, chronic systemic inflammation and dyslipidemia. As a result, they have been shown to be independent reciprocal risk factors. In addition, recent data have shown that NAFLD actively contributes to aggravation of the pathophysiology of CVD, T2DM, and CKD, as well as several other pathologies. Thus, NAFLD is a direct cause of many chronic diseases associated with MetS, and better detection and treatment of fatty liver disease is therefore urgently needed. As non-invasive screening methods for liver disease become increasingly available, detection and treatment of NAFLD in patients with MetS should therefore be considered by both (sub-) specialists and primary care physicians.
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影响因子：
3.7
作者：
Bonapace S;Valbusa F;Bertolini L;Pichiri I;Mantovani A;Rossi A;Zenari L;Barbieri E;Targher G
通讯作者：
Targher G
影响因子：
9.8
作者：
Adams, Leon A.;Harmsen, Scott;St Sauver, Jennifer L.;Charatcharoenwitthaya, Phunchai;Enders, Felicity B.;Therneau, Terry;Angulo, Paul
通讯作者：
Angulo, Paul
DOI：
10.1111/j.1440-1746.2008.05740.x
发表时间：
2009-02-01
影响因子：
4.1
作者：
Brzozowska, Malgorzata M.;Ostapowicz, George;Weltman, Martin D.
通讯作者：
Weltman, Martin D.
影响因子：
37.8
作者：
ALGRA, A;TIJSSEN, JGP;LUBSEN, J
通讯作者：
LUBSEN, J
影响因子：
13.5
作者：
Browning, JD;Szczepaniak, LS;Hobbs, HH
通讯作者：
Hobbs, HH