The preferential targeting of the diseased microvasculature by disk-like particles.
The preferential targeting of the diseased microvasculature by disk-like particles.
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DOI：
10.1016/j.biomaterials.2012.04.027
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发表时间：
2012-08
期刊：
影响因子：
14
通讯作者：
Decuzzi, Paolo
中科院分区：
文献类型：
--
作者：
Adriani, Giulia;de Tullio, Marco Donato;Ferrari, Mauro;Hussain, Fazle;Pascazio, Giuseppe;Liu, Xuewu;Decuzzi, Paolo
不同类别的纳米颗粒 (NP) 已被开发用于控制和改善治疗剂和造影剂的全身给药。颗粒形状已被证明对于纳米颗粒的血管运输和粘附至关重要。在这里，我们使用介孔硅非球形颗粒，形状为盘状和棒状，尺寸范围为 200 nm 至 1800 nm。详细描述了介孔颗粒的制备过程，并使用平行板流动室研究了它们在流动下的传输和粘附性能。数值模拟可以预测颗粒上的水动力，并有助于解释它们的独特行为。在微血管流动条件下，对于盘状形状，1000×400 nm的颗粒显示出最大的粘附力，而较小的（600×200 nm）和较大的（1800×600 nm）颗粒的粘附力较小，约为两倍。据观察，较大的棒 (1800×400 nm) 的粘附力是较小的棒 (1500×200 nm) 的至少 3 倍。对于相同体积的颗粒，盘状颗粒的粘附力大约是棒状颗粒的两倍。中等尺寸圆盘的最大粘附力反映了粘附界面相互作用和流体动力移动力之间的平衡。鉴于有关血管分子异质性的证据越来越多，目前的数据表明，与球体和细长棒相比，薄盘状颗粒可以更有效地靶向患病的微脉管系统。
Different classes of nanoparticles (NPs) have been developed for controlling and improving the systemic administration of therapeutic and contrast agents. Particle shape has been shown to be crucial in the vascular transport and adhesion of NPs. Here, we use mesoporous silicon non-spherical particles, of disk and rod shapes, ranging in size from 200 nm to 1800 nm. The fabrication process of the mesoporous particles is described in detail, and their transport and adhesion properties under flow are studied using a parallel plate flow chamber. Numerical simulations predict the hydrodynamic forces on the particles and help in interpreting their distinctive behaviors. Under microvascular flow conditions, for disk-like shape, 1000×400 nm particles show maximum adhesion, whereas smaller (600×200 nm) and larger (1800×600 nm) particles adhere less by a factor of about two. Larger rods (1800×400 nm) are observed to adhere at least 3 times more than smaller ones (1500×200 nm). For particles of equal volumes, disks adhere about 2 times more than rods. Maximum adhesion for intermediate sized disks reflects the balance between adhesive interfacial interactions and hydrodynamic dislodging forces. In view of the growing evidence on vascular molecular heterogeneity, the present data suggest that thin disk-like particles could more effectively target the diseased microvasculature as compared to spheres and slender rods.
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影响因子：
8
作者：
Boso, Daniela P.;Lee, Sei-Young;Decuzzi, Paolo
通讯作者：
Decuzzi, Paolo
影响因子：
16.1
作者：
Sergeeva, Anna;Kolonin, Mikhail G.;Molldrem, Jeffrey J.;Pasqualini, Renata;Arap, Wadih
通讯作者：
Arap, Wadih
影响因子：
64.8
作者：
Sengupta, S;Eavarone, D;Sasisekharan, R
通讯作者：
Sasisekharan, R
影响因子：
3.5
作者：
Lee, Sei-Young;Ferrari, Mauro;Decuzzi, Paolo
通讯作者：
Decuzzi, Paolo
影响因子：
2.9
作者：
SWARZTRAUBER, PN
通讯作者：
SWARZTRAUBER, PN