Molecular aspects of bacterial pH sensing and homeostasis.
Molecular aspects of bacterial pH sensing and homeostasis.
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DOI:
10.1038/nrmicro2549
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发表时间:
2011-05
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影响因子:
--
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Diverse mechanisms for pH-sensing and cytoplasmic pH homeostasis enable most bacteria to tolerate or grow at external pH values that are outside the cytoplasmic pH range they must maintain for growth. The most extreme cases are exemplified by the extremophiles that inhabit environments whose pH is below 3 or above 11. Here we describe how recent insights into the structure and function of key molecules and their regulators reveal novel strategies of bacterial pH-homeostasis. These insights may help us better target certain pathogens and better harness the capacities of environmental bacteria.
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