STIM- and Orai-mediated calcium entry controls NF-κB activity and function in lymphocytes.
STIM- and Orai-mediated calcium entry controls NF-κB activity and function in lymphocytes.
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DOI：
10.1016/j.ceca.2018.07.003
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发表时间：
2018-09
期刊：
影响因子：
4
通讯作者：
Freedman BD
中科院分区：
文献类型：
--
作者：
Berry CT;May MJ;Freedman BD
Ca 2+信号传导在功能性免疫和耐受性发展中的中心作用已得到充分确立。这些信号由抗原结合到淋巴细胞上的同源受体引发，所述同源受体触发钙池操纵的Ca 2+内流（SOCE）。淋巴细胞中SOCE的潜在机制涉及TCR和BCR介导的包埋在ER膜中的基质相互作用分子1和2（STIM 1/2）分子的活化，导致它们活化质膜中的奥赖通道。STIM/奥赖依赖性Ca 2+信号主要通过直接调节Ca 2+依赖性转录因子来指导关键抗原诱导的淋巴细胞发育和功能。Ca 2+信号在NFAT活化和信号传导中的作用是众所周知的，并且已经被广泛研究，但是对于Ca 2+信号如何也塑造NF-κB依赖性基因表达的活化和特异性的广泛理解和机制理解已经滞后。在这里，我们讨论和解释什么是已知的Ca 2+依赖性机制的NF-κ B激活，包括什么是已知的和差距，我们了解这些信号如何控制淋巴细胞的发育和功能。
The central role of Ca2+ signaling in the development of functional immunity and tolerance is well established. These signals are initiated by antigen binding to cognate receptors on lymphocytes that trigger store operated Ca2+ entry (SOCE). The underlying mechanism of SOCE in lymphocytes involves TCR and BCR mediated activation of Stromal Interaction Molecule 1 and 2 (STIM1/2) molecules embedded in the ER membrane leading to their activation of Orai channels in the plasma membrane. STIM/Orai dependent Ca2+ signals guide key antigen induced lymphocyte development and function principally through direct regulation of Ca2+ dependent transcription factors. The role of Ca2+ signaling in NFAT activation and signaling is well known and has been studied extensively, but a wide appreciation and mechanistic understanding of how Ca2+ signals also shape the activation and specificity of NF-κB dependent gene expression has lagged. Here we discuss and interpret what is known about Ca2+ dependent mechanisms of NF-kB activation, including what is known and the gaps in our understanding of how these signals control lymphocyte development and function.
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DOI：
10.1084/jem.20041538
发表时间：
2005-01-17
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
通讯作者：
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影响因子：
6
作者：
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通讯作者：
Carmody RJ
影响因子：
32.4
作者：
Dejardin, E;Droin, NM;Green, DR
通讯作者：
Green, DR
DOI：
10.1073/pnas.1205834109
发表时间：
2012-05-29
影响因子：
11.1
作者：
Bollig, Nadine;Bruestle, Anne;Lohoff, Michael
通讯作者：
Lohoff, Michael
影响因子：
64.8
作者：
Daniels, Mark A.;Teixeiro, Emma;Palmer, Ed
通讯作者：
Palmer, Ed